Fungal infections in bone marrow transplant patients.

Abstract:

PURPOSE OF REVIEW:Invasive fungal infections have become the leading infectious cause of death in recipients of hematopoietic cell transplantation. Several factors have led to a renaissance in the study of invasive fungal infections. The growing incidence of both commonly encountered as well as emerging pathogens and the lethality of these infections coupled with the unprecedented number of available broad-spectrum antifungal drugs has lent a renewed vigor and enthusiasm to attempts to understand the pathogenesis of these diseases and, by doing so, improve prevention, diagnosis, and treatment. The following is a review of the primary research published from 2003 to the present that is pertinent to invasive fungal infection in the setting of hematopoietic cell transplantation. RECENT FINDINGS:The main themes of published primary research during 2003 to the present include the efficacy and tolerability of antifungal prophylaxis, epidemiologic analyses of risk factors following nonmyeloablative preparative regimens, and more-detailed analyses of nonmyeloid immune responses. SUMMARY:Although few definitive recommendations emerged from the studies during the review period, these investigations do contribute to a greater understanding of the immunobiology of invasive fungal infection and of the utility and limitations of newer antifungal agents in the prophylaxis or treatment of invasive fungal infection.

journal_name

Curr Opin Infect Dis

authors

Brown JM

doi

10.1097/01.qco.0000136935.13662.af

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

347-52

issue

4

eissn

0951-7375

issn

1473-6527

pii

00001432-200408000-00012

journal_volume

17

pub_type

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