Schistosomiasis: from drug deployment to drug development.

abstract：PURPOSE OF REVIEW:This is a review of tafenoquine, a new antimalarial drug. Here we examine the recent literature supporting the use of tafenoquine and summarize the opportunities and challenges for its well tolerated use worldwide. RECENT FINDINGS:Tafenoquine was recently approved by the US Food and Drug Administrati...

journal_title：Current opinion in infectious diseases

authors： Chen V,Daily JP

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:We review the potential new diagnostic tools for determining the cause of pneumonia in the setting of community-acquired infection after outlining the limitation of currently available tests. RECENT FINDINGS:A number of new tools are on the horizon with the potential to overcome the problems of exist...

journal_title：Current opinion in infectious diseases

authors： Basnayake TL,Waterer GW

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Integrase strand transfer inhibitors (INSTIs) have become a key component of antiretroviral therapy since the approval of twice-daily raltegravir in 2007 and the more recent approval of elvitegravir in 2012. At the same time, a third compound, dolutegravir, is in late-phase clinical trials, being test...

journal_title：Current opinion in infectious diseases

authors： Quashie PK,Mesplède T,Wainberg MA

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to assess the recent studies of therapy of pregnant women and neonates, aimed at preventing the consequences of congenital cytomegalovirus (CMV) infection. RECENT FINDINGS:A recent randomized controlled trial of treatment of CMV during pregnancy with hyperimmune globulin...

journal_title：Current opinion in infectious diseases

authors： Rawlinson WD,Hamilton ST,van Zuylen WJ

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Clostridium difficile infection and Clostridium difficile-associated diarrhea (CDAD) are growing worldwide health threats. Recent studies have identified new host risk factors, diagnostic approaches and therapies of CDAD. The present review focuses on scientific papers published in the past 18 months ...

journal_title：Current opinion in infectious diseases

authors： DuPont HL,Garey K,Caeiro JP,Jiang ZD

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Several attempts have been made to combine drugs for treating visceral leishmaniasis, but only recently have effective drugs become available and combinations been tested systematically. RECENT FINDINGS:Sequential treatments with liposomal amphotericin B followed by miltefosine or paromomycin (as sho...

journal_title：Current opinion in infectious diseases

authors： Olliaro PL

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:As the evidence for two-drug regimens (2DR) for HIV treatment accumulates and 2DR start to enter consensus guidelines, this review covers the history, rationale and current evidence for 2DR in first-line and switch settings. RECENT FINDINGS:Until recently, most evidence for 2DR was for boosted protea...

journal_title：Current opinion in infectious diseases

authors： Waters L,Church H

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review describes the literature about the prevention of Staphylococcus aureus infections in surgery, published from August 2006 to January 2008, and puts it into perspective. RECENT FINDINGS:To prevent Staphylococcus aureus infections after surgical procedures, three methods were describe...

journal_title：Current opinion in infectious diseases

authors： van Rijen MM,Kluytmans JA

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the availability of new antifungals and improved antifungal formulations, there is a continued need for the development of new drugs to treat invasive fungal infections. In high-risk populations, including heavily immunocompromised patients, those with multiple comorbidities, and patients in i...

journal_title：Current opinion in infectious diseases

authors： Wiederhold NP,Patterson TF

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite diagnostic and therapeutic advances, acute haematogenous osteomyelitis in children continues to cause significant morbidity and disease burden. The molecular epidemiology of causal organisms has wide geographic variation, but regardless of cause children often require several weeks of inpatien...

journal_title：Current opinion in infectious diseases

authors： Weichert S,Sharland M,Clarke NM,Faust SN

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite progress in the management of pulmonary infections in the hematopoietic cell transplant (HCT) population, substantial diagnostic, and therapeutic uncertainty remains. RECENT FINDINGS:A growing HCT population reflects more transplants and improved long-term survival. We continue to learn about...

journal_title：Current opinion in infectious diseases

authors： Ford ES,Crothers K,Cheng GS

更新日期：2020-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Benzathine Penicillin G has been used to treat syphilis for over 50 years; however, the precise regimen of penicillin for treatment of syphilis in HIV-positive individuals remains a hot topic of debate. Although international guidelines recommend the same treatment for syphilis, regardless of HIV stat...

journal_title：Current opinion in infectious diseases

authors： Lawrence D,Cresswell F,Whetham J,Fisher M

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The immune reconstitution inflammatory syndrome (IRIS) is an important clinical complication in HIV-infected patients initiating antiretroviral therapy. This review focuses on the latest literature pertaining to the pathogenesis of IRIS. RECENT FINDINGS:The clinical manifestations of IRIS are heterog...

journal_title：Current opinion in infectious diseases

authors： Martin-Blondel G,Mars LT,Liblau RS

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:With increasing recognition of the importance of sexual networks in the dissemination of sexually transmitted infections (STIs), research is expanding. This review focuses on methodology for conducting sexual network research with in-depth presentations of recent and novel studies conducted on four co...

journal_title：Current opinion in infectious diseases

authors： Doherty IA

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will focus on the epidemiology and cause of diarrheal illness in solid organ transplant and stem-cell transplant population recipients with a specific focus on the role of advanced multiplex technology in the diagnosis of diarrhea within this patient population. RECENT FINDINGS:A wide ran...

journal_title：Current opinion in infectious diseases

authors： Santoiemma PP,Ison MG,Angarone MP

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Prion diseases such as Creutzfeldt-Jakob disease represent a unique infection control problem because prions exhibit an unusual resistance to conventional chemical and physical decontamination methods. This paper reviews the recent literature and provides recommendations for the prevention of nosocomi...

journal_title：Current opinion in infectious diseases

authors： Weber DJ,Rutala WA

更新日期：2002-08-01 00:00:00

abstract：:Otitis media is a very common reason for the prescription of antibiotics in children. Antimicrobial therapy is mostly empirical, based on the knowledge of the frequency and susceptibility patterns of causative pathogens and of the penetration and other pharmacokinetic properties of several oral antibiotics. Pharmacoec...

journal_title：Current opinion in infectious diseases

authors： Paradisi F,Corti G

更新日期：1998-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent findings in the management of active tuberculosis (TB) in solid organ transplant (SOT) recipients. RECENT FINDINGS:Mycobacterium tuberculosis causes substantial morbidity and mortality in SOT recipients. According to the literature, transplantation might not be an absolute contrai...

journal_title：Current opinion in infectious diseases

authors： Sun HY

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:It is now well established that cytokines play a critical role in the regulation of the immune system. Processes such as lymphoid development, differentiation, homeostasis, tolerance and memory are all regulated by cytokines that bind the type I family of cytokine receptors. Like the interferons, whic...

journal_title：Current opinion in infectious diseases

authors： Gadina M,Ferguson PR,Johnston JA

更新日期：2003-06-01 00:00:00

abstract：:Gram-positive cocci account for the large majority of cases of infective endocarditis. Pathogenesis investigations of endocarditis have therefore focused on purported virulence factors in staphylococci, viridans group streptococci and enterococci. In addition to novel molecular techniques that have been adapted for us...

journal_title：Current opinion in infectious diseases

authors： Baddour LM

更新日期：1999-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic pulmonary aspergillosis (CPA) is a relatively rare, slowly progressive pulmonary syndrome due to Aspergillus spp. that requires specific knowledge in terms of disease entity, diagnosis, management and azole resistance. This review focuses on the recent understanding of CPA entity and the emerg...

journal_title：Current opinion in infectious diseases

authors： Izumikawa K,Takazono T,Kohno S

更新日期：2010-12-01 00:00:00

abstract：:The best way to control chlamydial diseases is with an effective vaccine. Although previous studies suggest that a vaccine is an achievable goal, progress has been limited even though many vaccination strategies have been tested. A clearer understanding of the immunobiological basis of chlamydial protection and pathol...

journal_title：Current opinion in infectious diseases

authors： Yang X,Brunham RC

更新日期：1999-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Ventilator-associated pneumonia (VAP) is the most frequent cause of death among the nosocomial infections acquired in the ICU. Routine surveillance endotracheal aspirate (ETA) cultures in patients on mechanical ventilation have been proposed to predict the cause of VAP. Our aim is to review the availa...

journal_title：Current opinion in infectious diseases

authors： Luna CM,Bledel I,Raimondi A

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews recent developments in West Nile encephalitis. Because of the large number of individuals infected in the United States, an expanded spectrum of the disease has been recognized. Flaccid paralysis presenting as poliomyelitis-like syndrome is being increasingly recognized. RECENT F...

journal_title：Current opinion in infectious diseases

authors： Cunha BA

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Particularities of the fetal immune response to infection cause a heightened inflammatory state that acts synergistically with microbial insult to induce damage. Proteomics offers the opportunity for detecting fetuses at risk of sepsis and neurological injury. RECENT FINDINGS:Molecular tools (16S-rRN...

journal_title：Current opinion in infectious diseases

authors： Buhimschi CS,Bhandari V,Han YW,Dulay AT,Baumbusch MA,Madri JA,Buhimschi IA

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Pneumocystis pneumonia (PCP) is a frequent opportunistic infection associated with a high mortality rate. PCP is of increasing importance in non-HIV immunocompromised patients, who present with severe respiratory distress with low fungal loads. Molecular detection of Pneumocystis in broncho-alveolar l...

journal_title：Current opinion in infectious diseases

authors： Guegan H,Robert-Gangneux F

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Nontuberculous mycobacterial disease, especially pulmonary disease, is increasingly encountered by clinicians. Therapy of the most common nontuberculous mycobacterial pathogen, Mycobacterium avium complex, improved with the introduction of macrolide-containing regimens, but treatment for this and most...

journal_title：Current opinion in infectious diseases

authors： Griffith DE

更新日期：2007-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Cestodes infections in humans are among the most prevalent parasitosis worldwide. Although tapeworm infection is often asymptomatic, they can be associated with a range of symptoms. The landscape of cestode infections is changing with rapid diagnosis techniques and advanced molecular diagnosis aiding ...

journal_title：Current opinion in infectious diseases

authors： Webb C,Cabada MM

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Antimicrobial resistance (AMR) is a threat to global health and new approaches to combating AMR are needed. Use of machine learning in addressing AMR is in its infancy but has made promising steps. We reviewed the current literature on the use of machine learning for studying bacterial AMR. RECENT FI...

journal_title：Current opinion in infectious diseases

authors： Macesic N,Polubriaginof F,Tatonetti NP

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV postexposure prophylaxis is often recommended following potential sexual exposure to HIV. Recent data address the effectiveness of postexposure prophylaxis and prevention counseling, cost-effectiveness, antiretroviral options, challenges with nonoccupational postexposure prophylaxis among adolesce...

journal_title：Current opinion in infectious diseases

authors： Roland ME

更新日期：2007-02-01 00:00:00