Sexual networks and sexually transmitted infections: innovations and findings.

Abstract:

PURPOSE OF REVIEW:With increasing recognition of the importance of sexual networks in the dissemination of sexually transmitted infections (STIs), research is expanding. This review focuses on methodology for conducting sexual network research with in-depth presentations of recent and novel studies conducted on four continents. RECENT FINDINGS:Studies in diverse settings such as rural villages of China and St. Petersburg, Russia offer compelling evidence that HIV is no longer confined to needle-sharing and drug-using networks, but has diffused into the general population via heterosexual transmission. Because the networks are not especially densely connected, the shift will happen slowly. In contrast, studies conducted on both the east and west coasts of the US among men who have sex with men and women show that, despite high HIV prevalence, substance abuse, homelessness, and unprotected anal intercourse, the size of the population and sexual network dynamics are insufficient to cause widespread heterosexual HIV transmission. In Africa, holding low-risk positions in sexual networks can elevate the risk of infection, whereas higher-risk partnerships also simultaneously affect HIV transmission. SUMMARY:The diversity of findings in a diversity of settings demonstrates that not all networks operate in similar ways.

journal_name

Curr Opin Infect Dis

authors

Doherty IA

doi

10.1097/QCO.0b013e3283422647

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

70-7

issue

1

eissn

0951-7375

issn

1473-6527

journal_volume

24

pub_type

杂志文章,评审
  • Antimicrobial drug resistance in Salmonella enterica.

    abstract:PURPOSE OF REVIEW:This review addresses the changing patterns of antimicrobial resistance in Salmonella. RECENT FINDINGS:Resistance to chloramphenicol, amicillin and cotrimoxazole is common in Salmonella Typhi and Paratyphi A in Asia and a few countries of Africa. In some countries, the isolation of multidrug resistan...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200310000-00014

    authors: Parry CM

    更新日期:2003-10-01 00:00:00

  • Detecting latent tuberculosis in compromised patients.

    abstract:PURPOSE OF REVIEW:The detection of latent tuberculosis infection (LTBI) in different categories of compromised patients is reviewed with focus on the role of strategies incorporating immunodiagnostic tests and analysis of epidemiological and clinical risk factors. RECENT FINDINGS:The development of active tuberculosis...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000158

    authors: Sauzullo I,Vullo V,Mastroianni CM

    更新日期:2015-06-01 00:00:00

  • HIV and diarrhoea: what is new?

    abstract:PURPOSE OF REVIEW:The review examines the changing causes and the investigation of infectious and noninfectious diarrhoea in individuals with HIV. RECENT FINDINGS:Despite the excellent prognosis conferred by combination antiretroviral therapy, diarrhoea is still common in HIV-positive individuals and is associated wit...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000305

    authors: Logan C,Beadsworth MB,Beeching NJ

    更新日期:2016-10-01 00:00:00

  • Fractional-dose yellow fever vaccination: how much more can we do with less?

    abstract:PURPOSE OF REVIEW:Climate change, deforestation, urbanization, and increased population mobility have made the risk of large outbreaks of yellow fever more likely than ever. Yellow fever vaccine production barely meets demands. In this review, we address the causes of the recent yellow fever outbreaks, why fractional d...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000576

    authors: Visser LG

    更新日期:2019-10-01 00:00:00

  • Two drugs regimens for HIV.

    abstract:PURPOSE OF REVIEW:As the evidence for two-drug regimens (2DR) for HIV treatment accumulates and 2DR start to enter consensus guidelines, this review covers the history, rationale and current evidence for 2DR in first-line and switch settings. RECENT FINDINGS:Until recently, most evidence for 2DR was for boosted protea...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000615

    authors: Waters L,Church H

    更新日期:2020-02-01 00:00:00

  • Dolutegravir resistance mutations: lessons from monotherapy studies.

    abstract:PURPOSE OF REVIEW:Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (InSTI) with an outstanding antiviral potency, good tolerability, good pharmacokinetic profile with a lack of major drug-drug interactions, and a barrier to resistance higher than the other compounds of the class (raltegravi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000453

    authors: Blanco JL,Marcelin AG,Katlama C,Martinez E

    更新日期:2018-06-01 00:00:00

  • Current thinking on genital herpes.

    abstract:PURPOSE OF REVIEW:Genital herpes has a high global prevalence and burden of disease. This manuscript highlights recent advances in our understanding of genital herpes simplex virus (HSV) infections. RECENT FINDINGS:Studies demonstrate a changing epidemiological landscape with an increasing proportion of genital herpes...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000029

    authors: Hofstetter AM,Rosenthal SL,Stanberry LR

    更新日期:2014-02-01 00:00:00

  • Imiquimod.

    abstract:PURPOSE OF REVIEW:Imiquimod is the first member of a new class of immune response modifiers; it was first approved in 1997 for the topical treatment of external genital and perianal warts. It is an imidazoquinoline, a novel synthetic compound which is an immune response stimulator, enhancing both the innate and acquire...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200304000-00004

    authors: Garland SM

    更新日期:2003-04-01 00:00:00

  • Update on treatment of cytomegalovirus infection in pregnancy and of the newborn with congenital cytomegalovirus.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to assess the recent studies of therapy of pregnant women and neonates, aimed at preventing the consequences of congenital cytomegalovirus (CMV) infection. RECENT FINDINGS:A recent randomized controlled trial of treatment of CMV during pregnancy with hyperimmune globulin...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000317

    authors: Rawlinson WD,Hamilton ST,van Zuylen WJ

    更新日期:2016-12-01 00:00:00

  • Cardiac diseases complicating community-acquired pneumonia.

    abstract:PURPOSE OF REVIEW:The aim is to evaluate basic mechanisms, prevalence, risk factors, outcomes, and potential treatments of cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). RECENT FINDINGS:In this review, we present a new model to evaluate the pathophysiology of cardiac disease in patie...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000055

    authors: Aliberti S,Ramirez JA

    更新日期:2014-06-01 00:00:00

  • Immune responses in hepatitis C: is virus or host the problem?

    abstract:PURPOSE OF REVIEW:Hepatitis C virus is an RNA virus that usually establishes persistent infection in its host. As an important cause of cirrhosis and hepatocellular carcinoma worldwide, hepatitis C is a growing public health concern. Despite recent advances in therapy, most people infected with the virus can expect lif...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200406000-00004

    authors: Darling JM,Wright TL

    更新日期:2004-06-01 00:00:00

  • Advances in antimicrobial therapy of community-acquired pneumonia.

    abstract::Community-acquired pneumonia has a significant impact upon healthcare in North America and worldwide. In the U.S. it is responsible for three to four million cases yearly and 78,000 deaths. It is not a homogeneous entity and it may be caused by a number of pathogens including Streptococcus pneumoniae, the atypicals (M...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199904000-00006

    authors: Mandell LA

    更新日期:1999-04-01 00:00:00

  • New developments in the pathogenesis of acute exacerbations of chronic obstructive pulmonary disease.

    abstract:PURPOSE OF REVIEW:Acute exacerbations of chronic obstructive pulmonary disease were a poorly defined and understood entity. The application of better study designs and new research methodologies has shed considerable light on the pathogenesis of this common clinical syndrome. RECENT FINDINGS:Inflammation is an importa...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200404000-00008

    authors: Sethi S

    更新日期:2004-04-01 00:00:00

  • The company malaria keeps: how co-infection with Epstein-Barr virus leads to endemic Burkitt lymphoma.

    abstract:PURPOSE OF REVIEW:Co-infection with Plasmodium falciparum malaria and Epstein-Barr virus (EBV) are implicated in the cause of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in equatorial Africa. Although the causal association between EBV and eBL has been established, P. falciparum malaria's role i...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328349ac4f

    authors: Moormann AM,Snider CJ,Chelimo K

    更新日期:2011-10-01 00:00:00

  • New interleukins: are there any more?

    abstract:PURPOSE OF REVIEW:It is now well established that cytokines play a critical role in the regulation of the immune system. Processes such as lymphoid development, differentiation, homeostasis, tolerance and memory are all regulated by cytokines that bind the type I family of cytokine receptors. Like the interferons, whic...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200306000-00005

    authors: Gadina M,Ferguson PR,Johnston JA

    更新日期:2003-06-01 00:00:00

  • Recent developments in leishmaniasis.

    abstract:PURPOSE OF REVIEW:The leishmaniases, caused by protozoan parasites of the genus Leishmania, are a significant health problem in many regions of the world. This review highlights the recent advances in the study of leishmaniasis related to parasite biology, disease pathogenesis, clinical evaluation and treatment, and pr...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200210000-00005

    authors: Melby PC

    更新日期:2002-10-01 00:00:00

  • Risk stratification for multidrug-resistant Gram-negative infections in ICU patients.

    abstract:PURPOSE OF REVIEW:Antimicrobial resistance among Gram-negative microorganisms has alarmingly increased in the past 10 years worldwide. Infections caused by these microorganisms are difficult to treat, especially in critically ill patients.The present review examines how to accurately predict which patients carry a grea...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000599

    authors: Burillo A,Muñoz P,Bouza E

    更新日期:2019-12-01 00:00:00

  • Update on nonantibiotic therapies for acute gastroenteritis.

    abstract:PURPOSE OF REVIEW:The aim of this review is to provide an update of nonantibiotic therapies for acute gastroenteritis (AGE), focusing on antiemetics and probiotics. RECENT FINDINGS:The mainstay of therapy for nonsevere AGE remains oral rehydration therapy (ORT). Recent randomized controlled trials and metaanalyses hav...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000670

    authors: Funk A,Schnadower D,Freedman SB

    更新日期:2020-10-01 00:00:00

  • What is healthcare-associated pneumonia, and how should it be treated?

    abstract:PURPOSE OF REVIEW:In contrast to patients at risk for hospital-acquired pneumonia or mechanically ventilated patients at risk for ventilator-associated pneumonia, healthcare-associated pneumonia is a relatively new clinical entity that includes a spectrum of adult patients who have close association with acute care hos...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000216626.05821.40

    authors: Craven DE

    更新日期:2006-04-01 00:00:00

  • Molecular diagnosis of Pneumocystis pneumonia in immunocompromised patients.

    abstract:PURPOSE OF REVIEW:Pneumocystis pneumonia (PCP) is a frequent opportunistic infection associated with a high mortality rate. PCP is of increasing importance in non-HIV immunocompromised patients, who present with severe respiratory distress with low fungal loads. Molecular detection of Pneumocystis in broncho-alveolar l...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000559

    authors: Guegan H,Robert-Gangneux F

    更新日期:2019-08-01 00:00:00

  • Antifungal prophylaxis in neutropenia.

    abstract::Despite the widespread prophylactic use of antifungal agents in neutropenic patients, invasive fungal infections continue to emerge as major causes of morbidity and mortality. With the exception of fluconazole prophylaxis in allogeneic marrow transplant recipients, no firm conclusions can be drawn due to the lack of r...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199912000-00004

    authors: Maertens JA,Boogaerts MA

    更新日期:1999-12-01 00:00:00

  • Polyclonal and monoclonal antibodies for the treatment of influenza.

    abstract:PURPOSE OF REVIEW:This review summarizes past and ongoing efforts for using polyclonal and monoclonal antibodies for the treatment of influenza, and is focused on products that have entered clinical trials. RECENT FINDINGS:At least three polyclonal and eight monoclonal antibody products have been tested in clinical tr...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000499

    authors: Beigel JH

    更新日期:2018-12-01 00:00:00

  • New anti-hepatitis B virus drugs under development and evaluation.

    abstract:PURPOSE OF REVIEW:Although available therapies can effectively inhibit hepatitis B virus (HBV) replication in patients with active chronic hepatitis B (CHB) infection, therapeutic efficacy is limited because of potential drug resistance, and an inability to mediate viral clearance and to rectify immune impairment in CH...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000318

    authors: Pan J,Tong S,Kang L,Tang J

    更新日期:2016-12-01 00:00:00

  • Respiratory pathogen panels in the hospital: good or unnecessary?

    abstract:PURPOSE OF REVIEW:We aim to review the epidemiology of respiratory viral infections and the strengths and limitations of multiplex respiratory pathogen panels that are currently available along with their respective features and differences. RECENT FINDINGS:We give particular emphasis to the pathogens included on each...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000357

    authors: Cawcutt KA,Fey PD,Kalil AC

    更新日期:2017-04-01 00:00:00

  • New therapy options for MRSA with respiratory infection/pneumonia.

    abstract:PURPOSE OF REVIEW:Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent causative agent of nosocomial pneumonia. Because of important clinical consequences of inappropriate treatment, a current review of the potential modifications undergone by S. aureus and adaptation to new treatment options is necessary. ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283509cfa

    authors: Ramirez P,Fernández-Barat L,Torres A

    更新日期:2012-04-01 00:00:00

  • Update on group A streptococcal vaccine development.

    abstract:PURPOSE OF REVIEW:There is a global need for well tolerated, effective, and affordable vaccines to prevent group A streptococcal infections and their most serious complications. The aim of this review is to highlight the recent progress in the identification of promising vaccine antigens and new approaches to vaccine d...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000644

    authors: Dale JB,Walker MJ

    更新日期:2020-06-01 00:00:00

  • The interferon antiviral response: from viral invasion to evasion.

    abstract::One of the initial responses of an organism to infection by pathogenic viruses is the synthesis of antiviral cytokines such as the type I interferons (interferon-alpha/beta), interleukins, and other proinflammatory cytokines and chemokines. Interferons provide a first line of defence against virus infections by genera...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200206000-00008

    authors: Grandvaux N,tenOever BR,Servant MJ,Hiscott J

    更新日期:2002-06-01 00:00:00

  • The role of interleukin-10 in critical illness.

    abstract::Interleukin-10 is the most potent anti-inflammatory cytokine yet identified. It has multiple actions affecting the innate immune system as well as humoral and cellular immune responses. It occupies a pivotal role in the regulation of the immune response to microbial pathogens in health and disease. Knowledge gained in...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-200006000-00004

    authors: Opal SM,Huber CE

    更新日期:2000-06-01 00:00:00

  • Emerging multidrug-resistant Candida species.

    abstract:PURPOSE OF REVIEW:To describe the epidemiology, strategies for early detection, and clinical management of infections caused by the most commonly found multidrug-resistant (MDR) Candida spp. RECENT FINDINGS:Increasing numbers of reports describing invasive infections by MDR Candida auris and Candida glabrata has been ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000411

    authors: Colombo AL,Júnior JNA,Guinea J

    更新日期:2017-12-01 00:00:00

  • Infection control in countries with limited resources.

    abstract::Considerable progress has been made in the development of effective hospital infection control programs in countries with limited resources, most notably in Asia and Latin America. National nosocomial infection surveillance methods are now used in a variety of countries, particularly in Brazil, and offer a better meas...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199808000-00010

    authors: Huskins WC,Soule B

    更新日期:1998-08-01 00:00:00