Abstract:
PURPOSE OF REVIEW:Genital herpes has a high global prevalence and burden of disease. This manuscript highlights recent advances in our understanding of genital herpes simplex virus (HSV) infections. RECENT FINDINGS:Studies demonstrate a changing epidemiological landscape with an increasing proportion of genital herpes cases associated with HSV type 1. There is also growing evidence that the majority of infected individuals exhibit frequent, brief shedding episodes that are most often asymptomatic, which likely contribute to high HSV transmission rates. Given this finding as well as readily available serological assays, some have proposed that routine HSV screening be performed; however, this remains controversial and is not currently recommended. Host immune responses, particularly local CD4 and CD8 T cell activity, are crucial for HSV control and clearance following initial infection, during latency and after reactivation. Prior HSV immunity may also afford partial protection against HSV reinfection and disease. Although HSV vaccine trials have been disappointing to date and existing antiviral medications are limited, novel prophylactic and therapeutic modalities are currently in development. SUMMARY:Although much remains unknown about genital herpes, improved knowledge of HSV epidemiology, pathogenesis and host immunity may help guide new strategies for disease prevention and control.
journal_name
Curr Opin Infect Disjournal_title
Current opinion in infectious diseasesauthors
Hofstetter AM,Rosenthal SL,Stanberry LRdoi
10.1097/QCO.0000000000000029subject
Has Abstractpub_date
2014-02-01 00:00:00pages
75-83issue
1eissn
0951-7375issn
1473-6527journal_volume
27pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Skin and soft tissue infections (SSTIs) in patients with hematological malignancies are frequent, but dedicated epidemiological studies are limited. The aim of this review is to provide updated description of the main etiological agents, differential diagnosis, and treatment. RECENT FINDINGS:In addit...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/QCO.0000000000000632
更新日期:2020-04-01 00:00:00
abstract::Bone marrow transplant recipients are at increased risk of a variety of infections from endogenous and exogenous sources. Various practices, including the use of prophylactic agents and a controlled environment are often employed in the name of infection control. Comparable data are lacking because of non-unified defi...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200108000-00005
更新日期:2001-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Bacterial zoonoses are increasingly described in association with travel. Some bacterial zoonoses constitute important causes of post-travel illness. We focus on leptospirosis and rickettsiosis - the most common travel-associated bacterial zoonoses. RECENT FINDINGS:Leptospirosis is regarded to be the...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e32834a1bd2
更新日期:2011-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim is to evaluate basic mechanisms, prevalence, risk factors, outcomes, and potential treatments of cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). RECENT FINDINGS:In this review, we present a new model to evaluate the pathophysiology of cardiac disease in patie...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000055
更新日期:2014-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Clostridioides difficile infection (CDI) is a significant burden on the health system, especially due to high recurrence rates. Since the beginning of the CDI epidemic in early 2000s, many strategies for combatting recurrence have been explored, with moderate success so far. This review will focus on ...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000587
更新日期:2019-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Illicit drug use before or during sex - known as sexualized drug use (colloquially 'chemsex' or 'party and play') - has evolved as novel psychoactive substances have entered the market in many parts of the world. Here, we review key conceptual issues in associations between illicit drug use and sexual...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000234
更新日期:2016-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The present review summarizes key studies on the effects of major abdominal surgery on the host response to infection published during the last 18 months. RECENT FINDINGS:Surgical trauma causes stereotyped systemic proinflammatory and compensatory anti-inflammatory reactions. It is leukocyte reprogra...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e32833939cb
更新日期:2010-06-01 00:00:00
abstract::Head lice is an old problem that won't go away. Infestation with the head louse Pediculus capitis is still common in school-aged children. The majority of information about this condition is based on anecdotal evidence. There is a definite need for the standardization of detection methods for diagnosis and epidemiolog...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/00001432-200004000-00007
更新日期:2000-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent causative agent of nosocomial pneumonia. Because of important clinical consequences of inappropriate treatment, a current review of the potential modifications undergone by S. aureus and adaptation to new treatment options is necessary. ...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e3283509cfa
更新日期:2012-04-01 00:00:00
abstract:PURPOSE OF REVIEW:There is a global need for well tolerated, effective, and affordable vaccines to prevent group A streptococcal infections and their most serious complications. The aim of this review is to highlight the recent progress in the identification of promising vaccine antigens and new approaches to vaccine d...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/QCO.0000000000000644
更新日期:2020-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This review will focus on the epidemiology and cause of diarrheal illness in solid organ transplant and stem-cell transplant population recipients with a specific focus on the role of advanced multiplex technology in the diagnosis of diarrhea within this patient population. RECENT FINDINGS:A wide ran...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000586
更新日期:2019-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The review examines the changing causes and the investigation of infectious and noninfectious diarrhoea in individuals with HIV. RECENT FINDINGS:Despite the excellent prognosis conferred by combination antiretroviral therapy, diarrhoea is still common in HIV-positive individuals and is associated wit...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000305
更新日期:2016-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The emergence of 2009 pandemic H1N1 influenza A (pH1N1) has provided a unique challenge to influenza control in healthcare settings. We provide an overview of the early lessons from the 2009 pandemic. RECENT FINDINGS:The modes of influenza transmission and their contributions to the development of in...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e32833bb804
更新日期:2010-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize important papers concerning measles disease and measles-containing vaccines published in 2004. RECENT FINDINGS:Endemic measles has been successfully controlled in the Americas and, to a lesser extent, in Europe. This has been achieved with a high uptake of t...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/01.qco.0000168383.93647.47
更新日期:2005-06-01 00:00:00
abstract:PURPOSE OF REVIEW:New respiratory viruses have been discovered in recent years and new molecular diagnostic assays have been developed that improve our understanding of respiratory virus infections. This article will review the changing epidemiology of these viruses after hematopoietic stem cell and solid organ transpl...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e3283480440
更新日期:2011-08-01 00:00:00
abstract:PURPOSE OF REVIEW:This review focuses on some of the recent advances in the understanding of HIV immunopathogenesis and the diagnosis and treatment of several autoimmune conditions associated with HIV in the era of potent antiretroviral therapy. RECENT FINDINGS:Chronic immune activation with progressive immune exhaust...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e3283210006
更新日期:2009-02-01 00:00:00
abstract::Cystic fibrosis is the most common lethal inherited disorder with autosomal recessive inheritance. Major progress has been made in understanding the molecular mechanisms leading to increased susceptibility to Pseudomonas aeruginosa colonization. Persistent respiratory infection with P. aeruginosa leads to progressive ...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200204000-00013
更新日期:2002-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to provide an update on the public health impact of food-related illness in light of recent high-profile outbreaks and advances in the methodology to estimate illness burden. It includes mainly literature from high-income countries, as burden of illness estimations have b...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e328356aeba
更新日期:2012-10-01 00:00:00
abstract:PURPOSE OF REVIEW:As physicians are confronted with a diversity of adverse events and variability in response to medication among patients, this review will focus on the available evidence regarding the impact of genetic variation on drug response. Specifically, variation in drug metabolizing enzymes such as the cytoch...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/01.qco.0000191507.48481.10
更新日期:2005-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The success of male circumcision in reducing HIV acquisition among African heterosexuals has led to renewed interest in this biological intervention for HIV/sexually transmissible infection (STI) prevention in men who have sex with men (MSM). This review summarizes the available data on the associatio...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e328334e54d
更新日期:2010-02-01 00:00:00
abstract::The subject of bacterial skin infection in the tropics has shown some significant advances in the past few years, although it is still relatively understudied. Of special interest is the emerging concern about the public health aspects of pyoderma, either primary or secondary to scabies, in developing countries. In ad...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200104000-00002
更新日期:2001-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Pneumocystis pneumonia (PCP) is a frequent opportunistic infection associated with a high mortality rate. PCP is of increasing importance in non-HIV immunocompromised patients, who present with severe respiratory distress with low fungal loads. Molecular detection of Pneumocystis in broncho-alveolar l...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000559
更新日期:2019-08-01 00:00:00
abstract:PURPOSE OF REVIEW:We review the potential new diagnostic tools for determining the cause of pneumonia in the setting of community-acquired infection after outlining the limitation of currently available tests. RECENT FINDINGS:A number of new tools are on the horizon with the potential to overcome the problems of exist...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000148
更新日期:2015-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Benzathine Penicillin G has been used to treat syphilis for over 50 years; however, the precise regimen of penicillin for treatment of syphilis in HIV-positive individuals remains a hot topic of debate. Although international guidelines recommend the same treatment for syphilis, regardless of HIV stat...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000132
更新日期:2015-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Imiquimod is the first member of a new class of immune response modifiers; it was first approved in 1997 for the topical treatment of external genital and perianal warts. It is an imidazoquinoline, a novel synthetic compound which is an immune response stimulator, enhancing both the innate and acquire...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200304000-00004
更新日期:2003-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To explore recent developments in computerized evidence-based guidelines and decision support systems that have been designed to improve the effectiveness and efficiency of antibiotic prescribing. RECENT FINDINGS:The most frequently utilized decision support systems are electronic guidelines and prot...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/qco.0b013e3283118932
更新日期:2008-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The world's population is becoming increasing mobile. Each mobile population (e.g. immigrants, refugees, travelers) has certain characteristics that determine public health risk and infectious disease burden. Refugees present unique challenges to public health officials and infectious disease speciali...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e32832f14a4
更新日期:2009-10-01 00:00:00
abstract::Infections caused by Candida spp. are frequent and serious in oncology patients. Over the past decade, the introduction of azole antifungals as prophylactic agents, and other factors have caused a shift in the species of Candida that cause infection. During the period under review (June 1999 to June 2000), several stu...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/00001432-200012000-00006
更新日期:2000-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Necrotizing enterocolitis remains an enigmatic and potentially devastating condition with high morbidity and mortality. This review explores ways in which bacterial pathogens, together with gut microflora, influence the pathophysiology of necrotizing enterocolitis. Specifically, it examines the role o...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/01.qco.0000224823.73223.29
更新日期:2006-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To explore how ethical considerations, improved diagnostics and data from clinical trials might see the lowering of some of the barriers blocking a cure for HIV infection over the next 5 years. RECENT FINDINGS:Despite the recent well publicized but eventually disappointing case reports, there remains...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000123
更新日期:2015-02-01 00:00:00