Abstract:
PURPOSE OF REVIEW:This is a review of tafenoquine, a new antimalarial drug. Here we examine the recent literature supporting the use of tafenoquine and summarize the opportunities and challenges for its well tolerated use worldwide. RECENT FINDINGS:Tafenoquine was recently approved by the US Food and Drug Administration for the treatment of dormant liver stage (hypnozoite) in Plasmodium vivax and for malaria prophylaxis. Single-dose tafenoquine provides equivalent efficacy to 14 days of primaquine for radical cure in P. vivax, and it can be dosed weekly to prevent malaria. However, tafenoquine can only be used in patients with normal G6PD activity and is contraindicated in children and during pregnancy or in lactating mothers with infants of deficient or unknown G6PD status. SUMMARY:Tafenoquine's long half-life allows a single dose to achieve radical cure, and weekly dosing for chemoprophylaxis to provide an exciting therapeutic option for patient care and as a new weapon for malaria control/eradication programs. Global implementation of tafenoquine will require the development and validation of a robust, low-cost diagnostic to reliably identify G6PD-deficient individuals. In addition, studies on tafenoquine safety in children are needed.
journal_name
Curr Opin Infect Disjournal_title
Current opinion in infectious diseasesauthors
Chen V,Daily JPdoi
10.1097/QCO.0000000000000574subject
Has Abstractpub_date
2019-10-01 00:00:00pages
407-412issue
5eissn
0951-7375issn
1473-6527journal_volume
32pub_type
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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