Recent advances in vaccines against viral haemorrhagic fevers.

Abstract:

:Development of vaccines against viral haemorrhagic fevers is a public health priority. Recent advances in our knowledge of pathogenesis and of the immune responses elicited by these viruses emphasize the crucial role of the immune system in the control of infection, but also its probable involvement in pathogenesis. Several vaccine candidates against viral haemorrhagic fevers have been evaluated in animals during the past year. Together, these data suggest that a vaccine approach against viral haemorrhagic fevers is feasible, should induce well-balanced immune responses with cellular and humoral components, and should avoid the potential deleterious effects that are associated with such immune responses.

journal_name

Curr Opin Infect Dis

authors

Baize S,Marianneau P,Georges-Courbot MC,Deubel V

doi

10.1097/00001432-200110000-00003

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

513-8

issue

5

eissn

0951-7375

issn

1473-6527

journal_volume

14

pub_type

杂志文章,评审
  • Bacterial skin infections in a tropical environment.

    abstract::The subject of bacterial skin infection in the tropics has shown some significant advances in the past few years, although it is still relatively understudied. Of special interest is the emerging concern about the public health aspects of pyoderma, either primary or secondary to scabies, in developing countries. In ad...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200104000-00002

    authors: Mahé A

    更新日期:2001-04-01 00:00:00

  • Antibiotic stewardship: overcoming implementation barriers.

    abstract:PURPOSE OF REVIEW:Antimicrobial stewardship is now recognized as a formal strategy for curbing the upward trend in antibiotic resistance. Literature on antimicrobial stewardship has focused on areas of strategic importance and operational delivery. A number of barriers have been recognized in the implementation of succ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283483262

    authors: Bal AM,Gould IM

    更新日期:2011-08-01 00:00:00

  • What role do viruses play in nosocomial pneumonia?

    abstract:PURPOSE OF THE REVIEW:Viruses are an increasingly recognized cause of community-acquired pneumonia (CAP), but their exact role in nosocomial pneumonia is still debated. This review focuses on the role of viruses as a cause of nosocomial pneumonia. RECENT FINDINGS:Respiratory viruses may be responsible for healthcare-a...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000049

    authors: Luyt CE,Bréchot N,Chastre J

    更新日期:2014-04-01 00:00:00

  • Antimicrobial stewardship: bridging the gap between quality care and cost.

    abstract:PURPOSE OF REVIEW:Antibiotic resistance continues to rise, whereas development of new agents to counter it has slowed. A heightened need exists to maintain the effectiveness of currently available agents. This review focuses on the need for better antimicrobial stewardship, expected benefits of well designed antimicrob...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000393484.17894.05

    authors: Goff DA

    更新日期:2011-02-01 00:00:00

  • Tafenoquine: the new kid on the block.

    abstract:PURPOSE OF REVIEW:This is a review of tafenoquine, a new antimalarial drug. Here we examine the recent literature supporting the use of tafenoquine and summarize the opportunities and challenges for its well tolerated use worldwide. RECENT FINDINGS:Tafenoquine was recently approved by the US Food and Drug Administrati...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000574

    authors: Chen V,Daily JP

    更新日期:2019-10-01 00:00:00

  • Deconstructing the infection control bundles for the containment of carbapenem-resistant Enterobacteriaceae.

    abstract:PURPOSE OF REVIEW:Rates of carbapenem-resistant Enterobacteriaceae (CRE), especially Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negatives, have increased worldwide. Infections caused by these organisms have been associated with a high mortality, which might be due in part to the limited availability of an...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000431853.71500.77

    authors: Munoz-Price LS,Quinn JP

    更新日期:2013-08-01 00:00:00

  • Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future.

    abstract:PURPOSE OF REVIEW:Particularities of the fetal immune response to infection cause a heightened inflammatory state that acts synergistically with microbial insult to induce damage. Proteomics offers the opportunity for detecting fetuses at risk of sepsis and neurological injury. RECENT FINDINGS:Molecular tools (16S-rRN...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32832a5963

    authors: Buhimschi CS,Bhandari V,Han YW,Dulay AT,Baumbusch MA,Madri JA,Buhimschi IA

    更新日期:2009-06-01 00:00:00

  • The role of interleukin-10 in critical illness.

    abstract::Interleukin-10 is the most potent anti-inflammatory cytokine yet identified. It has multiple actions affecting the innate immune system as well as humoral and cellular immune responses. It occupies a pivotal role in the regulation of the immune response to microbial pathogens in health and disease. Knowledge gained in...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-200006000-00004

    authors: Opal SM,Huber CE

    更新日期:2000-06-01 00:00:00

  • Innate immune response to Burkholderia mallei.

    abstract:PURPOSE OF REVIEW:Burkholderia mallei is a facultative intracellular pathogen that causes the highly contagious and often the fatal disease, glanders. With its high rate of infectivity via aerosol and recalcitrance toward antibiotics, this pathogen is considered a potential biological threat agent. This review focuses ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000362

    authors: Saikh KU,Mott TM

    更新日期:2017-06-01 00:00:00

  • Antifungal prophylaxis in neutropenia.

    abstract::Despite the widespread prophylactic use of antifungal agents in neutropenic patients, invasive fungal infections continue to emerge as major causes of morbidity and mortality. With the exception of fluconazole prophylaxis in allogeneic marrow transplant recipients, no firm conclusions can be drawn due to the lack of r...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199912000-00004

    authors: Maertens JA,Boogaerts MA

    更新日期:1999-12-01 00:00:00

  • Carbapenem use in critically ill patients.

    abstract:PURPOSE OF REVIEW:To review available data on carbapenem use in ICU. Carbapenem is a broad spectrum well tolerated antibiotic family that keep an excellent activity to extended spectrum β-lactamases and AmpC hyperproducer and in susceptible Pseudomonas aeruginosa and Acinetobacter baumannii. It becomes a drug of choice...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000622

    authors: Patrier J,Timsit JF

    更新日期:2020-02-01 00:00:00

  • Gastrointestinal parasites in the immunocompromised.

    abstract:PURPOSE OF REVIEW:Parasites and other infections have many effects on the gastrointestinal tract of individuals who are immunocompromised. Few reviews focus on parasitic infections, which are covered here. RECENT FINDINGS:The review first examines recent advances in our understanding of the taxonomy, diagnosis and tre...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000182104.40128.18

    authors: Lewthwaite P,Gill GV,Hart CA,Beeching NJ

    更新日期:2005-10-01 00:00:00

  • Decision support systems for antibiotic prescribing.

    abstract:PURPOSE OF REVIEW:To explore recent developments in computerized evidence-based guidelines and decision support systems that have been designed to improve the effectiveness and efficiency of antibiotic prescribing. RECENT FINDINGS:The most frequently utilized decision support systems are electronic guidelines and prot...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/qco.0b013e3283118932

    authors: Sintchenko V,Coiera E,Gilbert GL

    更新日期:2008-12-01 00:00:00

  • Host determinants of antiretroviral drug activity.

    abstract:PURPOSE OF REVIEW:As physicians are confronted with a diversity of adverse events and variability in response to medication among patients, this review will focus on the available evidence regarding the impact of genetic variation on drug response. Specifically, variation in drug metabolizing enzymes such as the cytoch...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000191507.48481.10

    authors: Boffito M,Winston A,Owen A

    更新日期:2005-12-01 00:00:00

  • Community-acquired pneumonia in adults.

    abstract::Efforts to reduce hospitalization or the length of stay are common topics in papers published last year. Chlamydia pneumoniae is now recognized worldwide as a common pathogen in community-acquired pneumonia. A great variation in the frequency of various pathogens is found in different countries, stressing the importan...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199804000-00010

    authors: Holmberg H

    更新日期:1998-04-01 00:00:00

  • HIV outcomes among migrants from low-income and middle-income countries living in high-income countries: a review of recent evidence.

    abstract:PURPOSE OF REVIEW:Migrants living in high-income countries are disproportionately affected by HIV infection and frequently have characteristics associated with poor HIV clinical outcomes. HIV epidemiology among migrants is influenced by changes in migration patterns and variations in transmission risk behaviors. Here w...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000415

    authors: Ross J,Cunningham CO,Hanna DB

    更新日期:2018-02-01 00:00:00

  • Prolonged infusion of beta-lactam antibiotics for Gram-negative infections: rationale and evidence base.

    abstract:PURPOSE OF REVIEW:The aim of this review is to discuss the rationale of and current evidence for prolonged beta-lactam infusion in the management of Gram-negative infections. RECENT FINDINGS:Pharmacokinetic/pharmacodynamic (PK/PD) data from various in-vitro and in-vivo experimental studies conclusively support prolong...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000681

    authors: Abdul-Aziz MH,Portunato F,Roberts JA

    更新日期:2020-12-01 00:00:00

  • Infection control in countries with limited resources.

    abstract::Considerable progress has been made in the development of effective hospital infection control programs in countries with limited resources, most notably in Asia and Latin America. National nosocomial infection surveillance methods are now used in a variety of countries, particularly in Brazil, and offer a better meas...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199808000-00010

    authors: Huskins WC,Soule B

    更新日期:1998-08-01 00:00:00

  • Acute haematogenous osteomyelitis in children: is there any evidence for how long we should treat?

    abstract:PURPOSE OF REVIEW:Despite diagnostic and therapeutic advances, acute haematogenous osteomyelitis in children continues to cause significant morbidity and disease burden. The molecular epidemiology of causal organisms has wide geographic variation, but regardless of cause children often require several weeks of inpatien...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283005441

    authors: Weichert S,Sharland M,Clarke NM,Faust SN

    更新日期:2008-06-01 00:00:00

  • Postexposure prophylaxis after sexual exposure to HIV.

    abstract:PURPOSE OF REVIEW:HIV postexposure prophylaxis is often recommended following potential sexual exposure to HIV. Recent data address the effectiveness of postexposure prophylaxis and prevention counseling, cost-effectiveness, antiretroviral options, challenges with nonoccupational postexposure prophylaxis among adolesce...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328012c5e0

    authors: Roland ME

    更新日期:2007-02-01 00:00:00

  • Immune responses in hepatitis C: is virus or host the problem?

    abstract:PURPOSE OF REVIEW:Hepatitis C virus is an RNA virus that usually establishes persistent infection in its host. As an important cause of cirrhosis and hepatocellular carcinoma worldwide, hepatitis C is a growing public health concern. Despite recent advances in therapy, most people infected with the virus can expect lif...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200406000-00004

    authors: Darling JM,Wright TL

    更新日期:2004-06-01 00:00:00

  • Measles.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize important papers concerning measles disease and measles-containing vaccines published in 2004. RECENT FINDINGS:Endemic measles has been successfully controlled in the Americas and, to a lesser extent, in Europe. This has been achieved with a high uptake of t...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000168383.93647.47

    authors: Elliman D,Sengupta N

    更新日期:2005-06-01 00:00:00

  • Skin complications of Bacillus Calmette-Guérin immunization.

    abstract:PURPOSE OF REVIEW:Bacillus Calmette-Guerin (BCG) vaccination has been performed since 1921, and remains the best method of preventing severe infections caused by Mycobacterium tuberculosis. Tuberculosis, in its various forms, remains a public health problem, and more than 100 countries continue BCG vaccination in an ef...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000160895.97362.4f

    authors: Bellet JS,Prose NS

    更新日期:2005-04-01 00:00:00

  • Parasitic infections of the intestine.

    abstract::Intestinal protozoal infections cause significant disease not only in the tropics but also in immunocompromised hosts and returning travellers in the developed world. Precise diagnosis of protozoal intestinal infection by microscopy can be difficult. Enzyme immunoassays for antigen detection are being used for some pr...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200110000-00013

    authors: Schuster H,Chiodini PL

    更新日期:2001-10-01 00:00:00

  • 18F-Fluorodeoxyglucose positron emission tomography and infectious diseases: current applications and future perspectives.

    abstract:PURPOSE OF REVIEW:18F-Fluorodeoxyglucose positron emission tomography/computed tomography is a well-established technique for diagnosis and management of a number of neoplastic conditions. However, in recent years the body of literature regarding its potential role in infectious diseases has progressively increased, wi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000354

    authors: Bassetti M,Carnelutti A,Muser D,Righi E,Petrosillo N,Di Gregorio F,Werner TJ,Alavi A

    更新日期:2017-04-01 00:00:00

  • Viruses causing childhood diarrhoea in the developing world.

    abstract:PURPOSE OF REVIEW:Acute gastroenteritis is one of the leading causes of morbidity and mortality in children in the developing world. With improvements in hygiene and sanitation, the burden of disease due to bacterial and parasitic infections has decreased and an increasing proportion of diarrhoea hospitalizations are a...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328330662f

    authors: Ramani S,Kang G

    更新日期:2009-10-01 00:00:00

  • New anti-cancer therapies, new opportunities for infection.

    abstract::Therapeutic approaches in the practice of haematology/oncology are increasing in complexity. Agents such as the purine analogues and monoclonal antibodies may introduce a new spectrum of infection as a consequence of prolonged/profound lymphoid suppression. The use of high dose therapy with stem cells support is incre...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199908000-00009

    authors: Potter M

    更新日期:1999-08-01 00:00:00

  • Fungal infections in bone marrow transplant patients.

    abstract:PURPOSE OF REVIEW:Invasive fungal infections have become the leading infectious cause of death in recipients of hematopoietic cell transplantation. Several factors have led to a renaissance in the study of invasive fungal infections. The growing incidence of both commonly encountered as well as emerging pathogens and t...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000136935.13662.af

    authors: Brown JM

    更新日期:2004-08-01 00:00:00

  • Emerging clinical issues in refugees.

    abstract:PURPOSE OF REVIEW:The world's population is becoming increasing mobile. Each mobile population (e.g. immigrants, refugees, travelers) has certain characteristics that determine public health risk and infectious disease burden. Refugees present unique challenges to public health officials and infectious disease speciali...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32832f14a4

    authors: Stauffer WM,Weinberg M

    更新日期:2009-10-01 00:00:00

  • Approach to adenovirus infections in the setting of hematopoietic cell transplantation.

    abstract:PURPOSE OF REVIEW:To review risk-based pre-emptive treatment for adenovirus (ADV) based on quantitative PCR (qPCR) and to provide an update on clinical trials of brincidofovir (BCV) and ADV-specific cytotoxic T lymphocytes (ADV-CTLs). RECENT FINDINGS:ADV qPCR in various body compartments enables distinction of clinica...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000379

    authors: Lee YJ,Prockop SE,Papanicolaou GA

    更新日期:2017-08-01 00:00:00