Abstract:
:Stirred media milling is the main technology for producing colloidal nanocrystalline suspensions. A number of studies have been reported on the effect of different operating parameters for lab, pilot, and industrial scales. However, typical milling tool box that can be used to support candidate from selection up to phase III clinical supplies can involve different mill configurations. This article describes a parametric study and milling kinetic modelling of the different mills. The impact of active pharmaceutical ingredient (API) type and process parameters on milling kinetics was determined. The milling kinetics were modeled using an empirical model which allows for predicting and simulation of milling kinetics of stirred annular and pin mills. The proposed model was found to accurately fit milling kinetics whatever the API considered, technology employed, and the process parameters used for milling. Moreover, the model was found to be able to ensure the process transfer from one mill to another.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Nakach M,Authelin JR,Agut Cdoi
10.1016/j.xphs.2017.02.036subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1889-1904issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(17)30156-9journal_volume
106pub_type
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