Abstract：
:Approximately 30% of active pharmaceutical ingredients (APIs) experience agglomeration, granulation, and breakage during agitated drying. Currently, there is no small-scale bench tool to help assess and observe granulation behavior of APIs in the laboratory and subsequently lead to the development of a robust drying method. As a result, more conservative drying methods are usually used at scale and much longer drying times are needed. In this work, we build on work reported in the literature and demonstrate that a mixer torque rheometer (MTR) can be a useful small-scale tool to flag potentially problematic granulation behavior of APIs under different conditions. The results from the MTR were confirmed using a second new tool involving the use of an acoustic mixer to verify and observe the granulation behavior on a small scale. We also show consistency between the data collected at the laboratory and the pilot plant scales.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Zhang S,Lamberto DJdoi
10.1002/jps.23762subject
Has Abstractpub_date
2014-01-01 00:00:00pages
152-60issue
1eissn
0022-3549issn
1520-6017pii
S0022-3549(15)30749-8journal_volume
103pub_type
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