Abstract:
:The role of particle size and surface modification on biodistribution of nanocarriers is widely reported. We report for the first time the role of nanoparticle shape on biodistribution. Our study demonstrates that irregular shaped polymer lipid nanoparticles (LIPOMER) evade kupffer cells and localize in the spleen. We also demonstrate the macrophage-evading characteristic of the irregular-shaped LIPOMER. Our results suggest particle shape as an important tool for passive targeting of nanocarriers in splenotropic drug delivery.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Devarajan PV,Jindal AB,Patil RR,Mulla F,Gaikwad RV,Samad Adoi
10.1002/jps.22052subject
Has Abstractpub_date
2010-06-01 00:00:00pages
2576-81issue
6eissn
0022-3549issn
1520-6017pii
S0022-3549(15)32622-8journal_volume
99pub_type
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