Abstract:
:The recently developed hydrogen-bonding propensity tool in the Cambridge Structural Database software package (Mercury) was tested to predict polymorphs. The compounds for the study were chosen from a list of approximately 300 pharmaceutically important compounds, for which multiple crystal forms had not been previously reported. The hydrogen-bonding propensity analysis was carried out on approximately 60 randomly selected compounds from this list. Several compounds with a high probability for exhibiting polymorphism in the analysis were chosen for a limited experimental crystal form screening. One of the compounds, probenecid, did not yield polymorphs by traditional solution crystallization screening, but differential scanning calorimetry revealed three polymorphs. All of them exhibit the same hydrogen bonding and transform via two reversible single-crystal-to single-crystal transformations, which have been characterized in detail through three single-crystal structure determinations at appropriate temperatures.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Nauha E,Bernstein Jdoi
10.1002/jps.24449subject
Has Abstractpub_date
2015-06-01 00:00:00pages
2056-2061issue
6eissn
0022-3549issn
1520-6017pii
S0022-3549(15)30096-4journal_volume
104pub_type
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