Polyanhydride microsphere formulation by solvent extraction.

Abstract:

:A novel process based on solvent extraction was developed to produce drug-loaded polyanhydride microspheres for controlled-release applications. The technique consists of adding a chloroform solution of polyanhydride and drug into a stirred silicone oil phase containing suspended droplets of surfactant. No chemical reaction, heating, nor contact with water was required in this process. The microspheres produced were capable of releasing various dyes for prolonged periods of time.

journal_name

J Pharm Sci

authors

Bindschaedler C,Leong K,Mathiowitz E,Langer R

doi

10.1002/jps.2600770811

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

696-8

issue

8

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)47774-3

journal_volume

77

pub_type

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