Abstract:
:Flumizole is a potent anti-inflammatory agent in animal models with an inhibitory activity severalfold that of indomethacin in rat foot edema and prostaglandin synthetase tests. The drug was well absorbed from the GI tract when administered in the solution used in pharmacological assays. However, markedly poorer absorption of the solid form of this poorly water-soluble agent led to the development of a flumizole dispersion with polyethylene glycol 6000. The solid dispersion exhibited an increased dissolution rate in simulated gastric fluid and improved absorption properties in dogs relative to unformulated flumizole. Studies with a capsule formulation of the solid dispersion in human volunteers were indicative of good drug absorption. Plasma levels of flumizole were rapidly achieved and declined with a short half-life (2-7 hr) in rats, dogs, and humans.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Wiseman EH,McIlhenny HM,Bettis JWdoi
10.1002/jps.2600640909subject
Has Abstractpub_date
1975-09-01 00:00:00pages
1469-75issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(15)40391-0journal_volume
64pub_type
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