Abstract:
:The aim of this study is to explore hot melt extrusion (HME) as a solvent-free drug loading technique for preparation of stable amorphous solid dispersions using mesoporous silica (PSi). Ibuprofen and carvedilol were used as poorly soluble active pharmaceutical ingredients (APIs). Due to the high friction of an API:PSi mixture below the loading limit of the API, it was necessary to add the polymer Soluplus® (SOL) in order to enable the extrusion process. As a result, the APIs were distributed between the PSi and SOL phase after HME. Due to its higher affinity to PSi, ibuprofen was mainly adsorbed into the PSi, whereas carvedilol was mainly found in the SOL phase. Intrinsic dissolution rate was highest for HME formulations, containing PSi, compared to pure crystalline (amorphous) APIs and HME formulations without PSi. HME is a feasible solvent-free drug loading technique for preparation of PSi-based amorphous solid dispersions.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Genina N,Hadi B,Löbmann Kdoi
10.1016/j.xphs.2017.05.039subject
Has Abstractpub_date
2018-01-01 00:00:00pages
149-155issue
1eissn
0022-3549issn
1520-6017pii
S0022-3549(17)30434-3journal_volume
107pub_type
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