Engineering Stability, Viscosity, and Immunogenicity of Antibodies by Computational Design.


:In recent years, computational methods have garnered much attention in protein engineering. A large number of computational methods have been developed to analyze the sequences and structures of proteins and have been used to predict the various properties. Antibodies are one of the emergent protein therapeutics, and thus, methods to control their physicochemical properties are highly desirable. However, despite the tremendous efforts of past decades, computational methods to predict the physicochemical properties of antibodies are still in their infancy. Experimental validations are certainly required for real-world applications, and the results should be interpreted with caution. Among the various properties of antibodies, we focus in this review on stability, viscosity, and immunogenicity, and we present the current status of computational methods to engineer such properties.


J Pharm Sci


Kuroda D,Tsumoto K




Has Abstract


2020-05-01 00:00:00














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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


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  • The Use of Binary Polymeric Networks in Stabilizing Polyethylene Oxide Solid Dispersions.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


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    更新日期:2016-10-01 00:00:00

  • Protein adsorption, desorption, and aggregation mediated by solid-liquid interfaces.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


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    更新日期:2015-06-01 00:00:00

  • Preservative and Irritant Capacity of Biosurfactants From Different Sources: A Comparative Study.

    abstract::One of the most important challenges for pharmaceutical and cosmetic industries is solubilization and preservation of their active ingredients. Therefore, most of these formulations contain irritant chemical additives to improve their shelf-life and the solubility of hydrophobic ingredients. An interesting alternative...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rodríguez-López L,Rincón-Fontán M,Vecino X,Cruz JM,Moldes AB

    更新日期:2019-07-01 00:00:00