Abstract:
:The assay of suppositories containing pentobarbital and/or pyrilamine in a water-soluble polyethylene glycol base by high-pressure liquid chromatography is described. No extraction is required. The suppository is dissolved in the mobile phase. This solution is diluted with an internal standard stock solution containing phenobarbital. Chromatographic conditions include a C18 bonded microporous silica column and a mobile phase of 65% 4 x 10(-3) M n-butyl sodium sulfonate in 1% acetic acid and 35% acetonitrile. The procedure using commercial products gave results comparable to those obtained by GLC.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Block JH,Levine HL,Ayres JWdoi
10.1002/jps.2600680524subject
Has Abstractpub_date
1979-05-01 00:00:00pages
605-8issue
5eissn
0022-3549issn
1520-6017pii
S0022-3549(15)42649-8journal_volume
68pub_type
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