Abstract:
:Analytical methods based on the title reactions are reviewed, and the malonic acid-acetic anhydride system was selected for detailed study. It is postulated that carbon suboxide, O = C = C = C = O, formed by the action of acetic anhydride on malonic acid, is the effective reactive species in this system. Carbon suboxide was prepared and identified, and spectrophotometric observations of its reactions with tertiary amines are described. Aliphatic and aromatic tertiary amines generate colored products upon reaction with carbon suboxide in the presence of acetic anhydride. It was found that aliphatic tertiary amines form colors upon reaction with carbon suboxide in the absence of acetic anhydride, whereas aromatic tertiary amines require the presence of acetic anhydride.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Connors KA,Ifan Adoi
10.1002/jps.2600761018subject
Has Abstractpub_date
1987-10-01 00:00:00pages
834-8issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(15)47512-4journal_volume
76pub_type
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