Abstract:
:The adsorption of quinidine onto kaolin was studied as a function of pH in aqueous solutions in which the ionic strength was adjusted to 0.1. The interaction of quinidine with pectin also was investigated in water and in phosphate buffer; the buffer pH and ionic strength were adjusted to 6.5 and 0.1, respectively. The in vitro results indicated that quinidine was adsorbed onto kaolin. At the highest concentration studied, the extent of adsorption increased from 3.64 mg of quinidine adsorbed/g of adsorbent at pH 2.4 to an average of 5.81 mg/g in the pH 5.5-7.5 range. In the presence of electrolytes, the interaction of quinidine with pectin was relatively small (3-13% bound) as compared to studies performed in water (66-90% bound). The data indicate that some quinidine may be adsorbed when this drug is administered concurrently with kaolin-pectin preparations.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Bucci AJ,Myre SA,Tan HS,Shenouda LSdoi
10.1002/jps.2600700907subject
Has Abstractpub_date
1981-09-01 00:00:00pages
999-1002issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(15)43879-1journal_volume
70pub_type
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