Stability of Ceftazidime Pentahydrate Investigated by Thermal Analysis Techniques.

Abstract:

:Cephalosporins are among the most frequently used broad-spectrum antimicrobial agents. Ceftazidime is a semisynthetic β-lactam antibiotic for parenteral administration widely used in the clinical practice, which has been categorized as a third-generation cephalosporin antibiotic. This drug crystallizes as a pentahydrate and, as all cephalosporins, it is unstable and subject to hydrolytic degradation. Taking this into account, this study investigates the stability under 2 different conditions (high temperature and exposition to vacuum) by using various techniques, as thermal analysis, Raman spectroscopy, and X-ray powder diffraction supported by multivariate curve resolution. It was proved that ceftazidime pentahydrate is unstable under the studied variables, exhibiting several transformation processes, which were discussed in terms of the crystalline structure.

journal_name

J Pharm Sci

authors

Alves de Santana MS,Santiago de Oliveira Y,de Castro Fonseca J,Ferreira WC,Neto VS,Ayala AP

doi

10.1016/j.xphs.2019.11.018

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

1324-1329

issue

3

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(19)30798-1

journal_volume

109

pub_type

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