Abstract:
:Cephalosporins are among the most frequently used broad-spectrum antimicrobial agents. Ceftazidime is a semisynthetic β-lactam antibiotic for parenteral administration widely used in the clinical practice, which has been categorized as a third-generation cephalosporin antibiotic. This drug crystallizes as a pentahydrate and, as all cephalosporins, it is unstable and subject to hydrolytic degradation. Taking this into account, this study investigates the stability under 2 different conditions (high temperature and exposition to vacuum) by using various techniques, as thermal analysis, Raman spectroscopy, and X-ray powder diffraction supported by multivariate curve resolution. It was proved that ceftazidime pentahydrate is unstable under the studied variables, exhibiting several transformation processes, which were discussed in terms of the crystalline structure.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Alves de Santana MS,Santiago de Oliveira Y,de Castro Fonseca J,Ferreira WC,Neto VS,Ayala APdoi
10.1016/j.xphs.2019.11.018subject
Has Abstractpub_date
2020-03-01 00:00:00pages
1324-1329issue
3eissn
0022-3549issn
1520-6017pii
S0022-3549(19)30798-1journal_volume
109pub_type
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