Abstract:
:The release kinetics of a polymeric-controlled release device are determined by its geometry and dimensions. A method to calculate the required size and shape of diffusion-controlled dosage forms to achieve a particular release profile is presented. The diffusion parameters are determined for various drugs (theophylline, diltiazem hydrochloride and caffeine) with thin ethyl cellulose (EC) films, containing different plasticizers [dibutyl sebacate (DBS) and acetyl tributyl citrate (ATBC)]. Computer simulations are then used to predict the drug release kinetics from various dosage forms (e.g. microparticles and cylinders). The practical benefit of these simulations is to optimize the geometry and dimensions of a controlled release device without the need of experimental studies. To verify the theoretical predictions, the release kinetics of theophylline from EC/ATBC microparticles of different size have also been determined experimentally. Good agreement is found between theory and experiment, proving the validity of the presented method.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Siepmann J,Ainaoui A,Vergnaud JM,Bodmeier Rdoi
10.1021/js980006asubject
Has Abstractpub_date
1998-07-01 00:00:00pages
827-32issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(15)50595-9journal_volume
87pub_type
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