Abstract:
:Polymer shielded liposomes were investigated as detoxifying agents for the weak bases imipramine and dosulepin and the diprotic drug opipramol. In vitro binding measurements in the presence of human serum samples revealed that the liposomes reduced the free drug concentration of the weak bases (corrected for protein binding) by 88-93%. The reduction for opipramol was around 76%. The results demonstrate that polymer shielded liposomes composed of anionic lipids are widely useful for drug overdose treatment. Polyethylene glycol chain lengths of 2000 and 5000 for the polymer coatings were also explored, and chain length showed no evidence of affecting drug uptake by liposomes. Liposomes compete favorably with other binding targets for drugs, and pharmacokinetic considerations suggest that liposomes could reduce toxicity by transporting drugs from fast-equilibrating organs such as the heart to slow-equilibrating organs such as the fat, muscle, and skin.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Howell BA,Chauhan Adoi
10.1002/jps.21683subject
Has Abstractpub_date
2009-10-01 00:00:00pages
3718-29issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(16)33127-6journal_volume
98pub_type
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