Binding of imipramine, dosulepin, and opipramol to liposomes for overdose treatment.


:Polymer shielded liposomes were investigated as detoxifying agents for the weak bases imipramine and dosulepin and the diprotic drug opipramol. In vitro binding measurements in the presence of human serum samples revealed that the liposomes reduced the free drug concentration of the weak bases (corrected for protein binding) by 88-93%. The reduction for opipramol was around 76%. The results demonstrate that polymer shielded liposomes composed of anionic lipids are widely useful for drug overdose treatment. Polyethylene glycol chain lengths of 2000 and 5000 for the polymer coatings were also explored, and chain length showed no evidence of affecting drug uptake by liposomes. Liposomes compete favorably with other binding targets for drugs, and pharmacokinetic considerations suggest that liposomes could reduce toxicity by transporting drugs from fast-equilibrating organs such as the heart to slow-equilibrating organs such as the fat, muscle, and skin.


J Pharm Sci


Howell BA,Chauhan A




Has Abstract


2009-10-01 00:00:00














  • Aromatic-aromatic interaction of amitriptyline: implication of overdosed drug detoxification.

    abstract::The objectives of this work are to explore the pi-pi complexation of amitriptyline with pi electron-deficient aromatic rings and demonstrate the feasibility of pi-pi complexation for overdosed drug detoxification. Water-soluble oligochitosan was chemically modified with dinitrobenzenesulfonyl groups to induce selectiv...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lee DW,Flint J,Morey T,Dennis D,Partch R,Baney R

    更新日期:2005-02-01 00:00:00

  • Pharmacokinetics of ketoconazole administered intravenously to dogs and orally as tablet and solution to humans and dogs.

    abstract::The single-dose pharmacokinetics and bioavailability of three ketoconazole formulations were evaluated using HPLC in five healthy human volunteers and six male mongrel dogs. The human volunteers received 400 mg po of ketoconazole as tablet (Ktab) and solution (Ksol) formulations. The dogs received 400 mg po of Ktab an...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Baxter JG,Brass C,Schentag JJ,Slaughter RL

    更新日期:1986-05-01 00:00:00

  • Stereospecific metabolic reduction of ketones.

    abstract::The stereospecificity of the metabolic reduction of arylalkylketones was investigated. The ketones, propiophenone (I), phenyl-acetone (III), and 1-phenyl-1,2-propanedione (V) were reduced in vitro and in vivo in rats and rabbits to the corresponding alcohols, 1-phenyl-1-propanol (II), 1-phenyl-2-propanol (IV), and 1-p...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Prelusky DB,Coutts RT,Pasutto FM

    更新日期:1982-12-01 00:00:00

  • Quantitative Estimation of Plasma Free Drug Fraction in Patients With Varying Degrees of Hepatic Impairment: A Methodological Evaluation.

    abstract::Quantitative prediction of unbound drug fraction (fu) is essential for scaling pharmacokinetics through physiologically based approaches. However, few attempts have been made to evaluate the projection of fu values under pathological conditions. The primary objective of this study was to predict fu values (n = 105) of...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Li GF,Yu G,Li Y,Zheng Y,Zheng QS,Derendorf H

    更新日期:2018-07-01 00:00:00

  • Drug delivery via the mucous membranes of the oral cavity.

    abstract::The delivery of drugs via the mucous membranes lining the oral cavity (i.e., sublingual and buccal), with consideration of both systemic delivery and local therapy, is reviewed in this paper. The structure and composition of the mucosae at different sites in the oral cavity, factors affecting mucosal permeability, pen...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Harris D,Robinson JR

    更新日期:1992-01-01 00:00:00

  • Reduced hydrolytic lability of epoprostenol in the presence of cationic micelles.

    abstract::The rapid hydrolysis of epoprostenol to 6-keto-prostaglandin F1 alpha is hydronium ion-catalyzed even at pH 10 or higher. In the presence of 1.0% hexadecyltrimethylammonium chloride, the rate was reduced significantly (1580-fold at pH 2 and 283-fold at a physiological pH). This decrease in the hydrolysis rate is attri...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cho MJ

    更新日期:1982-04-01 00:00:00

  • Viscosity of xanthan gum solutions at low shear rates.

    abstract::The viscosity of xanthan gum solutions in the low shear region was investigated with the aid of a Couette instrument. All solutions were highly pseudoplastic . Solutions containing 0.3-0.5% of the gum exhibited a highly ordered phase at very low shear. Viscosity, the degree of pseudoplasticity , and the value of the t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Zatz JL,Knapp S

    更新日期:1984-04-01 00:00:00

  • Formulation of Granules for Site-Specific Delivery of an Antimicrobial Essential Oil to the Animal Intestinal Tract.

    abstract::Owing to proliferation of antibiotic-resistant bacteria, the use of antibiotics for livestock growth promotion is banned in many countries and alternatives to in-feed antibiotics are needed. Cinnamon essential oil exhibits strong in vitro antibacterial activity; however, direct addition of essential oils to animal fee...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ma YH,Wang Q,Gong J,Wu XY

    更新日期:2016-03-01 00:00:00

  • Agglomerative crystallization of ABT-510 in a partially miscible solvent system.

    abstract::A modification of wet agglomeration technique is developed and demonstrated by agglomerative crystallization process for a nonapeptide (ABT-510) to improve processing of needle like crystals. Our procedure involves exploiting partial miscibility of the crystallization solvent system for in situ generation of a wetting...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sheikh AY,Pal A,Viswanath S,Tolle JC

    更新日期:2008-03-01 00:00:00

  • Synthesis, physicochemical parameters, and in vitro evaluation of N1-p-chlorophenyl-N5-alkylbiguanides.

    abstract::A series of N1-p-chlorophenyl-N5-alkylbiguanides were synthesized as potential inhibitors of dental plaque. Partition coefficients and pKa values were determined by standard methods. Biological activity was evaluated against Streptococcus mutans, a pure strain of plaque-forming bacteria. All compounds were compared to...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Warner VD,Lynch DM,Ajemian RS

    更新日期:1976-07-01 00:00:00

  • In vitro and in vivo availability of commercial prednisone tablets.

    abstract::A three-way crossover bioavailability study was performed using nine adult male volunteers with three different commercial prednisone tablets. Plasma samples were assayed for prednisolone, the active metabolite of prednisone, by a radioimmunoassay method. Statistical analysis showed significant differences in the rate...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 临床试验,杂志文章


    authors: Sullivan TJ,Sakmar E,Albert KS,Blair DC,Wagner JG

    更新日期:1975-10-01 00:00:00

  • Biowaiver monographs for immediate release solid oral dosage forms: ethambutol dihydrochloride.

    abstract::Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing ethambutol dihydrochloride as the only active pharmaceutical ingredient (API) are reviewed. Ethambutol dihydrochloride is a Biopharmaceutics Cl...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Becker C,Dressman JB,Amidon GL,Junginger HE,Kopp S,Midha KK,Shah VP,Stavchansky S,Barends DM

    更新日期:2008-04-01 00:00:00

  • Prediction of the possibility of the second peak of drug plasma concentration time curve after iv bolus administration from the standpoint of the traditional multi-compartmental linear pharmacokinetics.

    abstract::It is shown that the existence of the second peak on the drug plasma concentration time curve C(p)(t) after iv bolus dosing can be explained by considering the traditional multi-compartmental linear pharmacokinetics. It was found that a direct solution of the general three-compartment model yields the second peak of C...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Berezhkovskiy LM

    更新日期:2008-06-01 00:00:00

  • Particle diffusional layer thickness in a USP dissolution apparatus II: a combined function of particle size and paddle speed.

    abstract::This work was to investigate the effects of particle size and paddle speed on the particle diffusional layer thickness h(app) in a USP dissolution apparatus II. After the determination of the powder dissolution rates of five size fractions of fenofibrate, including <20, 20-32, 32-45, 63-75, and 90-106 microm, the pres...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sheng JJ,Sirois PJ,Dressman JB,Amidon GL

    更新日期:2008-11-01 00:00:00

  • New Approach and Practical Modelling of Bead Milling Process for the Manufacturing of Nanocrystalline Suspensions.

    abstract::Stirred media milling is the main technology for producing colloidal nanocrystalline suspensions. A number of studies have been reported on the effect of different operating parameters for lab, pilot, and industrial scales. However, typical milling tool box that can be used to support candidate from selection up to ph...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Nakach M,Authelin JR,Agut C

    更新日期:2017-07-01 00:00:00

  • Influence of ambient moisture on the compaction behavior of microcrystalline cellulose powder undergoing uni-axial compression and roller-compaction: a comparative study using near-infrared spectroscopy.

    abstract::This study evaluates the effect of variation in the ambient moisture on the compaction behavior of microcrystalline cellulose (MCC) powder. The study was conducted by comparing the physico-mechanical properties of, and the near infrared (NIR) spectra collected on, compacts prepared by roller compaction with those coll...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gupta A,Peck GE,Miller RW,Morris KR

    更新日期:2005-10-01 00:00:00

  • A new method of dissolution in vitro, the "Bio-Dis" apparatus: comparison with the rotating bottle method and in vitro: in vivo correlations.

    abstract::The aim was to study a new method of dissolution in vitro, the "Bio-Dis" apparatus, and to compare it with the classical rotating bottle method. Several theophylline controlled-release drug dosage forms were studied. Dissolution testing was performed in increasing pH in standard conditions and after treatment with pea...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Esbelin B,Beyssac E,Aiache JM,Shiu GK,Skelly JP

    更新日期:1991-10-01 00:00:00

  • Studies on the structure of the complex of the boron neutron capture therapy drug, L-p-boronophenylalanine, with fructose and related carbohydrates: chemical and 13C NMR evidence for the beta-D-fructofuranose 2,3,6-(p-phenylalanylorthoboronate) structure.

    abstract::The complex of L-L-boronophenylalanine (L-p-BPA) with fructose has been used for the past 5 years in clinical trials of boron neutron capture therapy to treat both melanoma and glioblastoma multiforme. However, the structure of this complex in water buffered at physiologic pH has not been established. In the (1)H NMR ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Shull BK,Spielvogel DE,Head G,Gopalaswamy R,Sankar S,Devito K

    更新日期:2000-02-01 00:00:00

  • Determination of segregation tendency of granules using surface imaging.

    abstract::In this study, powder surface imaging was utilized in evaluation of particle size-related segregation behavior of granules during vibration and tableting processes. Altogether, eight granule batches were manufactured using a fluidized bed granulator. The particle size distribution of each batch was measured with sieve...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lakio S,Hatara J,Tervakangas H,Sandler N

    更新日期:2012-06-01 00:00:00

  • An Assessment of the Ability of Submicron- and Micron-Size Silicone Oil Droplets in Dropped Prefillable Syringes to Invoke Early- and Late-Stage Immune Responses.

    abstract::A number of biopharmaceuticals are available as lyophilized formulations along with a prefilled syringe (PFS) containing water for injection (WFI). Submicron- and micron-size droplets of lubricating silicone oil (SO) applied to the inner surface of the PFS barrel might migrate into the WFI, to which protein pharmaceut...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Krayukhina E,Yokoyama M,Hayashihara KK,Maruno T,Noda M,Watanabe H,Uchihashi T,Uchiyama S

    更新日期:2019-07-01 00:00:00

  • Combined Treatment of Tyrosine Kinase Inhibitor-Labeled Gold Nanorod Encapsulated Albumin With Laser Thermal Ablation in a Renal Cell Carcinoma Model.

    abstract::To characterize and evaluate human serum albumin-encapsulated nanoparticles for drug delivery of a tyrosine kinase inhibitor combined with induction of photothermal ablation combination therapy of renal cell carcinoma (RCC), nanoparticles of varying preparations and concentrations were characterized via zeta potential...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Callaghan C,Peralta D,Liu J,Mandava SH,Maddox M,Dash S,Tarr MA,Lee BR

    更新日期:2016-01-01 00:00:00

  • Constant returns to scale for prescription dispensing in U.S. community pharmacy.

    abstract::By using data from a sample of 1767 community pharmacies, a total cost function was estimated by a polynomial regression of total cost on output. The Cobb-Douglas production function was estimated by a multiple linear regression of natural logarithmic transformations of output on natural logarithmic transformation of ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lohrisch D,Shull SC,Smith MC

    更新日期:1976-02-01 00:00:00

  • Pseudopolymorphism and phase stability in four solid forms of (6R,7R)-7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-(Z)-2-methoxy- iminoacetamid]-3- [(4-carbamoyl-1-quinuclidinio)methyl]-8-oxo-5-thia-1-azabicyclo - [4,2,0]oct-2-ene-2-carboxylate (E1040).

    abstract::(6R,7R)-7-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-(Z)-2-methoxy- iminoacetamid]-3- [(4-carbamoyl-1-quinuclidinio)methyl]-8-oxo-5-thia-1-azabicyclo [4,2,0]oct-2-ene-2-carboxylate (1; E1040) was isolated as alpha-(decahydrate), beta-(pentahydrate), and gamma-form (anhydrate) crystals and the X-ray amorphous form. The relatio...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ashizawa K,Uchikawa K,Hattori T,Ishibashi Y,Sato T,Miyake Y

    更新日期:1989-11-01 00:00:00

  • Antitumor agents. XXXIV: Mechanism of action of bruceoside A and brusatol on nucleic acid metabolism of P-388 lymphocytic leukemia cells.

    abstract::The quassinoids bruceantin, brucein D, brucein E, bruceoside A, and brusatol significantly inhibited P-388 lymphocytic leukemic cell RNA and protein synthesis in tissue culture. However, DNA synthesis inhibition seemed to correlate more directly with the anti-neoplastic activity of these compounds in the in vivo P-338...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hall IH,Lee KH,Eigebaly SA,Imakura Y,Sumida Y,Wu RY

    更新日期:1979-07-01 00:00:00

  • Robust calibration design in the pharmaceutical quantitative measurements with near-infrared (NIR) spectroscopy: Avoiding the chemometric pitfalls.

    abstract::Quantification analysis with near-infrared (NIR) spectroscopy typically requires utilizing chemometric techniques, such as partial least squares (PLS) method, to achieve the desired selectivity. This article points out a major limitation of these statistical-based calibration methods. The limitation is that the techni...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Xiang D,Berry J,Buntz S,Gargiulo P,Cheney J,Joshi Y,Wabuyele B,Wu H,Hamed M,Hussain AS,Khan MA

    更新日期:2009-03-01 00:00:00

  • Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine.

    abstract::Personalized medicine aims to determine the most adequate treatment and dose regimen to obtain the maximum efficacy and minimum side effect by taking into account patients' characteristics. For numerous reasons, one being ethical and methodological hurdles in including specific populations in clinical trials, innovati...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Marsousi N,Desmeules JA,Rudaz S,Daali Y

    更新日期:2017-09-01 00:00:00

  • Cholesterol-Targeted Anticancer and Apoptotic Effects of Anionic and Polycationic Amphiphilic Cyclodextrin Nanoparticles.

    abstract::Amphiphilic cyclodextrins (CDs) are biocompatible derivatives of natural CDs and are able to form nanoparticles or polyplexes spontaneously. In this study, nanoparticles prepared from nonionic (6OCaproβCD) or cationic amphiphilic CD (PC βCDC6) were used comparatively to develop nanoparticles intended for breast cancer...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Varan G,Öncül S,Ercan A,Benito JM,Ortiz Mellet C,Bilensoy E

    更新日期:2016-10-01 00:00:00

  • Characterization of a Stable 2,2'-Azobis(2-Methylpropanenitrile) Degradant and Its Use to Monitor the Oxidative Environment During Forced Degradation Studies by Liquid Chromatography/Mass Spectrometry.

    abstract::Azo compounds are commonly used to study radical-mediated degradation of pharmaceutical compounds. The favorable chemical and physical properties of 2,2'-azobis(2-methylpropanenitrile) (AIBN) have made it one of the most widely used compound for these type of studies. This article describes the characterization of a s...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wells-Knecht KJ,Dunn D

    更新日期:2019-09-01 00:00:00

  • Antimicrobial properties of alkaloids from Xanthorhiza simplicissima.

    abstract::The organic extract of the whole plant Xanthorhiza simplicissima was found to exhibit good activity against the AIDS-related opportunistic pathogens Candida albicans, Cryptococcus neoformans, and Mycobacterium intracellularae. Bioassay-directed fractionation of the extract led to the isolation of the known alkaloid be...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Okunade AL,Hufford CD,Richardson MD,Peterson JR,Clark AM

    更新日期:1994-03-01 00:00:00

  • Calorimetric relaxation and the glass-liquid temperature range of acetaminophen-nifedipine alloys.

    abstract::Glassy states of nine acetaminophen-nifedipine compositions have been made by slowly supercooling their melts, and calorimetric T(g) and the nonexponential, nonlinear relaxation parameters beta and x that are used in modeling the mobility of a pharmaceutical determined. The T(g)-endotherm's shape varies with the alloy...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Johari GP,Shanker RM

    更新日期:2008-08-01 00:00:00