Abstract:
:A potentiometric study of lithium complexation with tyramine, dopamine, norepinephrine, and 5-hydroxytryptamine was undertaken using monovalent cationic selective and pH glass electrodes. The conditional stability constants for the lithium catecholamine complexes were calculated for a range of pH values from direct potentiometric measurement of the free lithium ion concentration. The ionic strength was maintained at 0.5 with tetramethylammonium chloride and glycine buffers. Temperature was maintained at 25 degrees C. Titration data for the catecholamines and lithium-catecholamine complexes at the same temperature and ionic strength were also obtained using tetramethylammonium hydroxide as titrant. All solutions were maintained essentially oxygen free during the analytical procedure. Alkali metals are generally recognized as being weakly complexed in aqueous solution. The magnitude of the stability constants determined in this study indicates there is a weak interaction of lithium with catecholamines.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Sandmann BJ,Luk HTdoi
10.1002/jps.2600750117subject
Has Abstractpub_date
1986-01-01 00:00:00pages
73-7issue
1eissn
0022-3549issn
1520-6017pii
S0022-3549(15)47003-0journal_volume
75pub_type
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