Abstract:
:The dissolution rates of a number of drug-urethan solid-state dispersion systems were studied. A marked enhancement of the initial dissolution rates of several poorly water-soluble drugs was found when they were incorporated into a urethan matrix by heat fusion. These differences were considerable when pure substances such as griseofulvin, hydrocortisone, chloramphenicol, and acetaminophen were compared to the urethan-drug solid dispersion. Physical mixtures of the medicinal agents with urethan also gave a marked increase in the amount of drug in solution, with the value in most cases being over one-half that of the solid-state dispersion. Data are given, comparing ultrafiltration with samples filtered through cotton, regarding drug content remaining in solution.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Maulding HVdoi
10.1002/jps.2600670332subject
Has Abstractpub_date
1978-03-01 00:00:00pages
391-4issue
3eissn
0022-3549issn
1520-6017pii
S0022-3549(15)39890-7journal_volume
67pub_type
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