Abstract:
:Mixture response-surface methodology can be used as a technique to predict solubility in mixed solvent systems. The present report shows that if the intent is to predict solubility in nonideal solutions, mixture response-surface methodology is a better technique than one which assumes a particular mechanism to hold true. This is demonstrated by comparing the predictive ability of the mixture response-surface model with that of an extended Hildebrand approach to nonideal solutions. The nonideal systems are those used by Martin and co-workers involving the solubility of theobromine, caffeine, and theophylline in dioxane-water mixtures.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Ochsner AB,Belloto RJ Jr,Sokoloski TDdoi
10.1002/jps.2600740206subject
Has Abstractpub_date
1985-02-01 00:00:00pages
132-5issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(15)46593-1journal_volume
74pub_type
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journal_title:Journal of pharmaceutical sciences
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journal_title:Journal of pharmaceutical sciences
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