Prediction of xanthine solubilities using statistical techniques.


:Mixture response-surface methodology can be used as a technique to predict solubility in mixed solvent systems. The present report shows that if the intent is to predict solubility in nonideal solutions, mixture response-surface methodology is a better technique than one which assumes a particular mechanism to hold true. This is demonstrated by comparing the predictive ability of the mixture response-surface model with that of an extended Hildebrand approach to nonideal solutions. The nonideal systems are those used by Martin and co-workers involving the solubility of theobromine, caffeine, and theophylline in dioxane-water mixtures.


J Pharm Sci


Ochsner AB,Belloto RJ Jr,Sokoloski TD




Has Abstract


1985-02-01 00:00:00














  • The Hypotonic Environmental Changes Affect Liposomal Formulations for Nose-to-Brain Targeted Drug Delivery.

    abstract::Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as drugs absorbed in the olfactory epithelium bypass the blood-brain barrier and reach the brain within...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wu IY,Nikolaisen TE,Škalko-Basnet N,di Cagno MP

    更新日期:2019-08-01 00:00:00

  • Structural studies of commercial fat emulsions used in parenteral nutrition.

    abstract::In this paper, we demonstrate that by employing a combination of sedimentation field-flow fractionation (sedFFF) and other characterization techniques, such as photon correlation spectroscopy (PCS) and freeze-fracture electron microscopy (EM), it is possible to show that commercial fat emulsions of similar overall che...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Li J,Caldwell KD

    更新日期:1994-11-01 00:00:00

  • Kinetics and mechanism of the equilibrium reaction of triazolam in aqueous solution.

    abstract::The equilibrium kinetics of triazolam in aqueous solution was investigated in the pH range of 1-11 at body temperature. The quantitative study indicated that it forms equilibrium mixtures consisting of ring-opened and closed forms with the composition being dependent on pH. The equilibrium constants of the two species...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Konishi M,Hirai K,Mori Y

    更新日期:1982-12-01 00:00:00

  • Synthesis and antibacterial evaluation of 2-(substituted phenylureido)-4-thiocyanatobenzothiazoles.

    abstract::The synthesis and antibacterial evaluation of a number of 2-(substituted phenylureido)-4-thiocyanatobenzothiazoles are described. The more active compounds against the test organisms in vitro generally were those substituted with halogens on the phenyl and benzothiazole rings. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Alaimo RJ,Pelosi SS,Freedman R

    更新日期:1978-02-01 00:00:00

  • Pharmacokinetics of aniracetam and its metabolites in rats.

    abstract::The pharmacokinetics of aniracetam (AP), a new cognitive performance enhancer, and its main metabolites was investigated after intravenous (iv) and oral administrations to rat. The plasma levels of AP, 4-p-anisamidobutyric acid (ABA), and p-anisic acid (AA) were determined simultaneously by the HPLC method. The plasma...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ogiso T,Iwaki M,Tanino T,Ikeda K,Paku T,Horibe Y,Suzuki H

    更新日期:1998-05-01 00:00:00

  • Effect of dispersion on the coloring properties of aluminum dye lakes.

    abstract::The effect of particle size on the coloring properties of aluminum dye lakes was studied. Lakes impart color by dispersion in the medium to be colored. Dispersion techniques were developed, using scanning electron micrographs for particle sizing. The color strength and the trichromatic colorimetric properties were cal...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wou LL,Mulley BA

    更新日期:1988-10-01 00:00:00

  • High-performance liquid chromatographic assay for N-acetylcysteine in plasma and urine.

    abstract::A sensitive high-performance liquid chromatographic (HPLC) assay for N-acetylcysteine in human plasma and urine has been developed. The method employs a prechromatographic stage to produce the dinitrophenyl derivative of N-acetylcysteine, which is chromatographed on a 5-microns C18 bonded reverse-phase column using an...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lewis PA,Woodward AJ,Maddock J

    更新日期:1984-07-01 00:00:00

  • Design of Hollow Hyaluronic Acid Cylinders for Sustained Intravitreal Protein Delivery.

    abstract::A hollow cylinder intravitreal implant was developed to achieve sustained release of protein to the retina for the treatment of retinal diseases. Hollow cylinders were fabricated by molding and cross-linking hyaluronic acid, the major component of the vitreous humor. Hollow cylinders were filled with a concentrated pr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Van Kampen E,Vandervelden C,Fakhari A,Qian J,Berkland C,Gehrke SH

    更新日期:2018-09-01 00:00:00

  • Explanation of the crystallization rate of amorphous nifedipine and phenobarbital from their molecular mobility as measured by (13)C nuclear magnetic resonance relaxation time and the relaxation time obtained from the heating rate dependence of the glass

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Aso Y,Yoshioka S,Kojima S

    更新日期:2001-06-01 00:00:00

  • Preparation, identification, and quantitative NMR determination of silyl derivatives of 6-aminopenicillanic acid, 7-amino-3-methyl-delta3-cephem-4-carboxylic acid, and 7-amino-3-acetoxymethyl-delta3-cephem-4-carboxylic acid.

    abstract::A rapid and accurate method for the quantitative determination of the extent and ratio of amino and carboxyl group trimethylsilylation of 6-aminopenicillanic acid, 7-amino-3-methyl-delta3-cephem-4-carboxylic acid, and 7-amino-3-acetoxymethyl-delta3-cephem-4-carboxylic acid is presented. The method utilizes NMR spectro...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bortesi F,Cavalli S,Mangia A

    更新日期:1977-12-01 00:00:00

  • Feasibility of atomic force microscopy for determining crystal growth rates of nifedipine at the surface of amorphous solids with and without polymers.

    abstract::Amorphous nifedipine (NFD), which has a smooth surface immediately after preparation, was shown to have structures resembling clusters of curling and branching fibers approximately 1 μm wide by atomic force microscopy (AFM) after storage at 25°C. The size of the cluster-like structures increased with storage over time...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Miyazaki T,Aso Y,Kawanishi T

    更新日期:2011-10-01 00:00:00

  • Synthesis of N,N'-bis(3-substituted benzylideneaminopropyl)-piperazines and their anti-inflammatory, antiproteolytic, and anticonvulsant properties.

    abstract::Some N,N'-bis(3-substituted benzylideneaminopropyl) piperazines were synthesized and characterized by their sharp melting points and elemental analyses. These substituted piperazines possessed anti-inflammatory activity, and the protection afforded by these compounds against carrageenan-induced edema ranged from 23 to...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chaturvedi AK,Sastry BV,Chaudhari A,Parmar SS

    更新日期:1976-03-01 00:00:00

  • Simultaneously manufactured nano-in-micro (SIMANIM) particles for dry-powder modified-release delivery of antibodies.

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    authors: Kaye RS,Purewal TS,Alpar HO

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    authors: Lim SM,Eom HN,Jiang HH,Sohn M,Lee KC

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  • Concomitant adsorption and stability of some anthracycline antibiotics.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Tomlinson E,Malspeis L

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  • Titanium dioxide-montmorillonite nanocomposite as photoprotective agent against ultraviolet B radiation-induced mutagenesis in Saccharomyces cerevisiae: a potential candidate for safer sunscreens.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Paiva JP,Santos BA,Kibwila DM,Gonçalves TC,Pinto AV,Rodrigues CR,Leitão AC,Cabral LM,De Pádula M

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  • A new potential prodrug to improve the duration of L-dopa: L-3-(3-hydroxy-4-pivaloyloxyphenyl)alanine.

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    authors: Ihara M,Tsuchiya Y,Sawasaki Y,Hisaka A,Takehana H,Tomimoto K,Yano M

    更新日期:1989-07-01 00:00:00

  • Detection of a minor amorphous phase in crystalline etoricoxib by dynamic mechanical analysis: comparison with Raman spectroscopy and modulated differential scanning calorimetry.

    abstract::Detection and quantification of the amorphous phase of etoricoxib bulk drug substances, a selective cycloogenase-2 inhibitor used for the treatment of osteoarthritis, rheumatoid arthritis, and dental pain, was carried out using modulated differential scanning calorimetry (MDSC), dynamic mechanical analysis (DMA), and ...

    journal_title:Journal of pharmaceutical sciences

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    authors: Clas SD,Lalonde K,Khougaz K,Dalton CR,Bilbeisi R

    更新日期:2012-02-01 00:00:00

  • Controlled and complete release of a model poorly water-soluble drug, prednisolone, from hydroxypropyl methylcellulose matrix tablets using (SBE)(7m)-beta-cyclodextrin as a solubilizing agent.

    abstract::Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)-based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug in the hydrophilic matrix. Sulfobutylether-beta-cyclodextrins ((SBE)(7M)-beta-CDs...

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  • Drug delivery trends in clinical trials and translational medicine: Updated analysis of database.

    abstract::While the number of clinical trials has continued to grow by about 20% in the past six months, no corresponding growth in product approval by the food and drug administration is seen or anticipated in the near future. Late-stage clinical failures due to lack of efficacy or toxicity continues to be a challenge. The opt...

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  • Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation.

    abstract::Recent studies have clearly demonstrated that Fourier transform IR spectroscopy can be a powerful tool for the study of protein stabilization during freeze-drying and for optimizing approaches to prevent lyophilization-induced protein aggregation. The purpose of the current review is to provide an overview of these to...

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    authors: Dong A,Prestrelski SJ,Allison SD,Carpenter JF

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  • Density and Shape Factor Terms in Stokes' Equation for Aerodynamic Behavior of Aerosols.

    abstract::Pharmaceutical aerosols are used to treat many pulmonary diseases. The use of low-density powders has proven useful to support efficient drug delivery. Measurements must account for the low-density, spherical particle features contributing to aerodynamic behavior. Ideally, the aerodynamic particle size distribution (A...

    journal_title:Journal of pharmaceutical sciences

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    authors: Hickey AJ,Edwards DA

    更新日期:2018-03-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ivashikiv E

    更新日期:1978-07-01 00:00:00

  • Thermodynamics of water-solid interactions in crystalline and amorphous pharmaceutical materials.

    abstract::Pharmaceutical materials, crystalline and amorphous, sorb water from the atmosphere, which affects critical factors in the development of drugs, such as the selection of drug substance crystal form, compatibility with excipients, dosage form selection, packaging, and product shelf-life. It is common practice to quanti...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sacchetti M

    更新日期:2014-09-01 00:00:00

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    abstract::Avoiding unwanted immunogenicity is of key importance in the development of therapeutic drug proteins. Animal models are of less predictive value because most of the drug proteins are recognized as foreign proteins. However, different methods have been developed to obtain immunotolerant animal models. So far, the immu...

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Choong TC,Thompson BL,Shough HR

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Krishnan R,Lang SA Jr

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  • GLC determination of methenamine in tablets.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Strom JG Jr,Jun HW

    更新日期:1977-04-01 00:00:00