Prediction of xanthine solubilities using statistical techniques.

Abstract:

:Mixture response-surface methodology can be used as a technique to predict solubility in mixed solvent systems. The present report shows that if the intent is to predict solubility in nonideal solutions, mixture response-surface methodology is a better technique than one which assumes a particular mechanism to hold true. This is demonstrated by comparing the predictive ability of the mixture response-surface model with that of an extended Hildebrand approach to nonideal solutions. The nonideal systems are those used by Martin and co-workers involving the solubility of theobromine, caffeine, and theophylline in dioxane-water mixtures.

journal_name

J Pharm Sci

authors

Ochsner AB,Belloto RJ Jr,Sokoloski TD

doi

10.1002/jps.2600740206

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

132-5

issue

2

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)46593-1

journal_volume

74

pub_type

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