Abstract:
:The pharmacokinetics of erythromycin and erythromycin 2'-propanoate were studied in healthy male volunteers following single and repeated doses of erythromycin stearate tablets, erythromycin estolate capsules, and a suspension. Estolate dosages gave rise to higher plasma levels of total drug than the stearate. However, the stearate yielded higher plasma levels of erythromycin base. Absorption of all dosage forms, except the suspension, was delayed, and pharmacokinetic interpretation of both single- and multiple-dose data required incorporation of an absorption lag time. The absorption of erythromycin stearate was inhibited by food and also by low fluid volumes in fasted subjects. Absorption of erythromycin estolate was increased in the presence of food and was not greatly affected by fluid volume. Although single-dose data poorly predicted circulating levels of erythromycin following repeated doses, trends observed after single doses were maintained during chronic treatment.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Welling PG,Elliott RL,Pitterle ME,Corrick-West HP,Lyons LLdoi
10.1002/jps.2600680208subject
Has Abstractpub_date
1979-02-01 00:00:00pages
150-5issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(15)42499-2journal_volume
68pub_type
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