Abstract:
:The oral absorption of drugs has been represented by various concepts such as the absorption potential, the maximum absorbable dose, the biopharmaceutics classification system, and in vitro-in vivo correlation. The aim of this article is to provide an overview of the theoretical relationships between these concepts. It shows how a simple analytical solution for the fraction of a dose absorbed (Fa equation) can offer a theoretical base to tie together the various concepts, and discusses how this solution relates to the rate-limiting cases of oral drug absorption. The article introduces the Fa classification system as a framework in which all the above concepts were included, and discusses its applications for food effect prediction, active pharmaceutical ingredient form selection, formulation design, and biowaiver strategy.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Sugano K,Terada Kdoi
10.1002/jps.24391subject
Has Abstractpub_date
2015-09-01 00:00:00pages
2777-88issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(16)30057-0journal_volume
104pub_type
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