High-pressure liquid chromatographic determination of cimetidine in plasma and urine.


:An assay is described for the determination of the H2-receptor antagonist, cimetidine, in human plasma and urine. Alkalinized plasma or urine was extracted with methylene chloride, the organic phase was evaporated, and the reconstituted residue was analysed by high-pressure liquid chromatography (HPLC) using a reversed-phase prepacked plastic column housed in a radial compression module. The metabolite, cimetidine sulfoxide, was identified but could not be quantitated due to interference from the solvent front. The sensitivity limit of the assay was 25 ng/ml. The assay was applied to the measurement of plasma and urine samples in a pilot pharmacokinetic study. Cimetidine was substantially absorbed and rapidly eliminated (plasma elimination half-life of 112-130 min). Plasma cimetidine concentrations could be measured to 12 hr after a 200-mg dose (iv or oral), but they were below the sensitivity of the assay by 24 hr. Urinary excretion of unmetabolized cimetidine accounted for 40-50% of the administered dose in the first 12 hr. This assay is simpler and more sensitive than those previously described, and it is suitable for the measurement of cimetidine in plasma and urine of subjects receiving doses appropriate for clinical use.


J Pharm Sci


Mihaly GW,Cockbain S,Jones DB,Hanson RG,Smallwood RA




Has Abstract


1982-05-01 00:00:00














  • Correlation of log P with molecular connectivity in hydroxyureas: influence of conformational system on log P.

    abstract::The correlation of log P (in octanol--water) with the nonempirical, topologically dependent, calculated molecular connectivity index (1chiv) delineates substituted hydroxyureas into two families of linearly related groups of compounds. The first group, composed of the 3-substituted ethyl, n-propyl, and n-butyl analogs...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Parker GR

    更新日期:1978-04-01 00:00:00

  • Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide.

    abstract::Melanotan-II (1) is a cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (alpha-MSH) which tans the skin and is currently being evaluated for the prevention of sunlight-induced skin cancers. The dissociation constants of 1 were determined using potentiometric titration and ultraviolet spectrophotomet...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lan EL,Ugwu SO,Blanchard J,Fang X,Hruby VJ,Sharma S

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  • Liquid chromatographic assay and disposition of carvedilol in healthy volunteers.

    abstract::Quantitative determination of serum concentrations of carvedilol [(+/-)-1-(carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl) amino]-2-propanol], a combined alpha- and beta-adrenergic receptor antagonist, was obtained using HPLC with spectrofluorometric detection. Carvedilol was extracted from alkalinized serum with eth...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Varin F,Cubeddu LX,Powell JR

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  • Vehicle effects in percutaneous absorption: in vitro study of influence of solvent power and microscopic viscosity of vehicle on benzocaine release from suspension hydrogels.

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    authors: Di Colo G,Carelli V,Giannaccini B,Serafini MF,Bottari F

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  • Exploration and Preparation of a Dose-Flexible Regulation System for Levetiracetam Tablets via Novel Semi-Solid Extrusion Three-Dimensional Printing.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Vashi VI,Meyer MC

    更新日期:1988-09-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

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    authors: Bylund J,Bueters T

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    journal_title:Journal of pharmaceutical sciences

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    authors: Sasaki Y,Shinohara Y,Baba S

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    journal_title:Journal of pharmaceutical sciences

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    authors: Hansson AG,Giardino A,Cardinal JR,Curatolo W

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    journal_title:Journal of pharmaceutical sciences

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    authors: Whyatt PL,Slywka GW,Melikian AP,Meyer MC

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    journal_title:Journal of pharmaceutical sciences

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    journal_title:Journal of pharmaceutical sciences

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    authors: Niazi S

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    journal_title:Journal of pharmaceutical sciences

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    authors: Veng-Pedersen P,Gillespie WR

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    journal_title:Journal of pharmaceutical sciences

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    journal_title:Journal of pharmaceutical sciences

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    pub_type: 杂志文章


    authors: Belal S,Elsayed MA,El-Waliely A,Abdine H

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    authors: Feth MP,Volz J,Hess U,Sturm E,Hummel RP

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Thelen K,Jantratid E,Dressman JB,Lippert J,Willmann S

    更新日期:2010-06-01 00:00:00