Abstract：
:We report a semiquantitative method for determining trace amounts (<1%) of thermodynamically stable forms in polymorphic mixtures, focusing on sample preparation effects on solid phase transitions. Tegafur [5-fluoro-1-(oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione] was used as a model material in this study. The amounts of the thermodynamically stable β tegafur were increased to levels detectable by powder X-ray diffractometry by grinding the samples in a ball mill in the presence of water. The limit of detection for this method was as low as 0.0005% of β tegafur in α and β tegafur mixtures. The amount of β tegafur after sample preparation was found to be proportional to the initial weight fraction of β tegafur. The sum of Langmuir and Cauchy-Lorentz equations was used to describe the change in conversion degree due to the added water volume, where Langmuir equation described water sorption during the sample preparation and Cauchy-Lorentz equation described the grinding efficiency.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Bobrovs R,Actiņš Adoi
10.1002/jps.23323subject
Has Abstractpub_date
2012-12-01 00:00:00pages
4608-14issue
12eissn
0022-3549issn
1520-6017pii
S0022-3549(15)31310-1journal_volume
101pub_type
杂志文章abstract：:Hemoglobin microcapsules were prepared through cross-linking of hemoglobin itself with various acyldichlorides. Variations in the reticulation conditions were preformed in order to ameliorate the oxygen dissociation curve, the mean diameter, and the possibility for the microcapsules to be lyophilized. With terephthalo...
journal_title：Journal of pharmaceutical sciences
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abstract：:The structural integrity and conformational stability of various IgG1-Fc proteins produced from the yeast Pichia pastoris with different glycosylation site occupancy (di-, mono-, and nonglycosylated) were determined. In addition, the physical stability profiles of three different forms of nonglycosylated Fc molecules ...
journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.23221
更新日期：2012-08-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1988-01-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600700324
更新日期：1981-03-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.1002/jps.2600790211
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.1002/jps.2600640711
更新日期：1975-07-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.23766
更新日期：2014-01-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600730614
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.21884
更新日期：2010-02-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1002/jps.2600670212
更新日期：1978-02-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.1002/jps.2600660431
更新日期：1977-04-01 00:00:00
abstract：:Aerosolized medicine is one of the fastest growing areas in the pharmaceutical industry. Dry powder aerosols of pharmaceutical compounds are particularly attractive for the prevention and treatment of respiratory diseases but are also emerging as a treatment option for systemic diseases. Engineering particles in dry p...
journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.1002/jps.23168
更新日期：2012-09-01 00:00:00
