Kinetics and mechanism of oxidation of promazine and promethazine by ferric perchlorate.

Abstract:

:The equilibrium constants, kinetics, and mechanism of promazine and promethazine oxidation by ferric perchlorate were investigated at different temperatures and acidities using a stopped-flow spectrophotometric technique. The overall reaction can be represented as follows: (formula: see text) where P+ represents the radical cation corresponding to the phenothiazine derivative. The equilibrium quotients were evaluated at 1.00 M HClO4, 25.0 degrees, and ionic strength 1.0 M. The kinetics of reaction follow the equation: -d[P] divided by dt = k1[Fe3+][P]-k-1[Fe2+][P+] The rate constants k1 and k-1 are independent of acidity and are related to the corresponding equilibrium quotients.

journal_name

J Pharm Sci

authors

Gasco MR,Carlotti ME

doi

10.1002/jps.2600670212

subject

Has Abstract

pub_date

1978-02-01 00:00:00

pages

168-71

issue

2

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)39814-2

journal_volume

67

pub_type

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