Abstract：
:Packing behavior and flowability of particulate material have long been acknowledged as important parameters for the processing of pharmaceutical materials. When properly understood, these properties can provide insight into weight uniformity, tableting performance and process design. The aim of this study was to measure particle size and shape distributions of different granular intermediates with a dynamic particle size image analyzer, and then use these distributions to predict packing efficiency and different metrics of flowability by employing partial least squares (PLS) modeling. From measurements of size and shape, a model was constructed that allowed for the prediction of flowability indices, bulk and tap densities with a high degree of accuracy for the granular materials used. In this study the use of size and shape distributions in the construction of a model providing both accurate flowability indices and bulk and tap density estimates has been demonstrated for example granular materials in which cohesive forces did not dominate powder behavior. It is believed that the continued application of the outlined experimental design would eventually lead to the fundamental understanding of how size and shape characteristics of materials influence particle behavior including downstream processibility.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Sandler N,Wilson Ddoi
10.1002/jps.21884subject
Has Abstractpub_date
2010-02-01 00:00:00pages
958-68issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(16)30394-Xjournal_volume
99pub_type
杂志文章abstract：:A new extraction-spectrophotometric method for the determination of hydralazine, based on its reaction with 2-hydroxy-1-naphthaldehyde at 25 degrees C, is described. The calibration curve was linear between 0.4 and 6 mg/mL of hydralazine. The molar absorbtivity of the product at 408 nm is 40,900 L.mol-1.cm-1. The meth...
journal_title：Journal of pharmaceutical sciences
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更新日期：1983-10-01 00:00:00
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更新日期：2016-09-01 00:00:00
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更新日期：2019-11-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.1059
更新日期：2001-08-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.1002/jps.2600801103
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600640423
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.1002/jps.2600651231
更新日期：1976-12-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1016/j.xphs.2019.10.016
更新日期：2020-01-01 00:00:00
abstract：:2',7'-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) is a fluorescent probe used to examine multidrug resistance-associated protein (MRP) transporter activity in cells. BCECF is introduced into the cell as the nonfluorescent membrane permeable acetoxymethyl ester, BCECF-AM, where it is hydrolyzed to the membrane ...
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journal_title：Journal of pharmaceutical sciences
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更新日期：2012-09-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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更新日期：1986-11-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600820110
更新日期：1993-01-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.21261
更新日期：2008-09-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.10316
更新日期：2003-03-01 00:00:00
