Abstract:
:A sensitive and very rapid assay for acetaminophen was developed based on the combination of high-performance chromatographic columns with a thin-layer electrochemical detector. Application to liquid and solid dosage forms and body fluids has been demonstrated. Great advantage derives from the detector selectivity, which permits discrimination against many potentially interfering substances without need for extensive separations or formation of derivatives. As little as 0.005% of the hydrolysis product, p-aminophenol, can be detected in the presence of the intact drug following cation-exchange chromatography. Acetaminophen can be quantitatively determined in serum on the 50-ng/ml level by liquid chromatography using a pellicular polyamide packing.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Riggin RM,Schmidt AL,Kissinger PTdoi
10.1002/jps.2600640423subject
Has Abstractpub_date
1975-04-01 00:00:00pages
680-3issue
4eissn
0022-3549issn
1520-6017pii
S0022-3549(15)40136-4journal_volume
64pub_type
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abstract::A rapid and simple high-performance liquid chromatographic (HPLC) method for the analysis of dichlorophen in raw material and in dichlorophen-toluene soft gelatin capsules for veterinary use was developed using a reverse-phase technique. This HPLC system was shown to isolate dichlorophen from its major impurity (the t...
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