Micro and macro GLC determination of ethambutol in biological fluids.

Abstract:

:Previously available GLC methods for ethambutol may only be used to measure quantities of drugs much greater than those found in biological fluids such as plasma and dialysate. A previously published GLC method for plasma samples is extended to measure ethambutol in dialysate. A second GLC method, involving derivatization with bis(trimethylsilyl)trifluoroacetamide and subsequent quantitation using a flame-ionization detector, is described for urine samples. With a dual-column and dual-detector gas--liquid chromatograph, simultaneous micro (plasma and dialysate) and macro (urine) determinations of ethambutol are possible.

journal_name

J Pharm Sci

authors

Lee CS,Benet LZ

doi

10.1002/jps.2600670407

subject

Has Abstract

pub_date

1978-04-01 00:00:00

pages

470-3

issue

4

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)39945-7

journal_volume

67

pub_type

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