Abstract:
:The bioavailability of clofibric acid from formulations containing calcium clofibrate along and mixed with calcium carbonate (1:1 w/w) was compared to that from a standard clofibrate formulation in a crossover study in 12 human subjects. The 95% confidence intervals of bioavailability differences were such that they were unlikely to be detected in clinical practice; all three formulations may be considered bioequivalent, although the bioavailability rate was probably greater from the formulation containing calcium clofibrate alone. Peaks of mean concentrations of 80 +/- 13,67 +/- 16, and 64 +/- 18 microgram/ml +/- SD occurred after administration of 853 mg of clofibric acid calcium salt alone, 809 mg of clofibric acid calcium salt mixed with calcium carbonate, and 885 mg of clofibrate, respectively; mean concentrations declined from peak levels with half-lives of 15-17 hr.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Taylor T,Chasseaud LFdoi
10.1002/jps.2600661138subject
Has Abstractpub_date
1977-11-01 00:00:00pages
1638-9issue
11eissn
0022-3549issn
1520-6017pii
S0022-3549(15)39661-1journal_volume
66pub_type
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