Modeling of transmitted X-ray intensity variation with sample thickness and solid fraction in glycine compacts.


:The previous paper in this series introduced an X-ray diffraction quantitation method for the polymorphic content in tablets made of pure components. Before the method could be transferred, further studies were required to explain the commonly observed X-ray intensity variation in analyzing compacts. The literature typically attributes the variation to partial amorphization under compression and/or to preferred orientation, without much viable explanation or compelling evidence. In this study, changes in intensity in compacts analyzed in transmission geometry were found to be primarily a function of sample thickness and solid fraction. A theoretical model was developed to describe the X-ray powder diffraction (XRPD) intensity as a function of solid fraction, mass absorption coefficient, and thickness. The model was tested on two sets of glycine compacts: one with varying thickness at constant solid fraction, and the other with various solid fractions at a given thickness. The results show that the model predicts the XRPD intensity at any given sample thickness and solid fraction. With this model, the intensity variation of compacts made under different compression conditions can be normalized, making the method transferable to various tablet geometries and facilitating the analysis over expected ranges of formulation and process variation.


J Pharm Sci


Cao W,Mullarney MP,Hancock BC,Bates S,Morris KR




Has Abstract


2003-12-01 00:00:00














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    abstract::Male and female rats treated with a single 20-mg/kg ip dose of pregnenolone-16alpha-carbonitrile (PCN) produced parallel increases in hepatic cytochrome P-450 and aniline hydroxylase activity. However, the onset of increase in aniline hydroxylase activity and cytochrome P-450 content was slower in male than female ani...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Stohs SJ,Rosenberg H

    更新日期:1976-04-01 00:00:00

  • Establishment of a Drug-Induced, Bile Acid-Dependent Hepatotoxicity Model Using HepaRG Cells.

    abstract::Bile acid (BA) retention within hepatocytes is an underlying mechanism of cholestatic drug-induced liver injury (DILI). We previously developed an assay using sandwich-cultured human hepatocytes (SCHHs) to evaluate drug-induced hepatocyte toxicity accompanying intracellular BA accumulation. However, due to shortcoming...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Susukida T,Sekine S,Nozaki M,Tokizono M,Oizumi K,Horie T,Ito K

    更新日期:2016-04-01 00:00:00

  • A novel multivariate approach for estimating the degree of similarity in bioavailability between two pharmaceutical products.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hsu HC,Lu HL,Chan KK

    更新日期:1995-06-01 00:00:00

  • Solubility and partitioning. VII: Solubility of barbiturates in water.

    abstract::The solubility equation of Yalkowsky was used to estimate the aqueous solubility of 33 barbiturates in the temperature range of 5 to 45 degrees C. The equation was extended by adding a term which accounts for the effect of pH on the solubility of the drug. The extended equation is successful in estimating the aqueous ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pinal R,Yalkowsky SH

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  • Overall monotropic behavior of a metastable phase of biclotymol, 2,2'-methylenebis(4-chloro-3-methyl-isopropylphenol), inferred from experimental and topological construction of the related P-T state diagram.

    abstract::The melt from the usual monoclinic phase (Phase I) of biclotymol (T(fusI) = 400.5 +/- 1.0 K, Delta(fus)H(I) = 36.6 +/- 0.9 kJ mol(-1)) recrystallizes into another phase, Phase II, that melts at T(fusII) = 373.8 +/- 0.2 K (Delta(fus)H(II) = 28.8 +/- 1.0 kJ mol(-1)). The transformation of Phase II into Phase I is found ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Céolin R,Tamarit JL,Barrio M,López DO,Nicolaï B,Veglio N,Perrin MA,Espeau P

    更新日期:2008-09-01 00:00:00

  • Analysis of transcutaneous antigenic protein delivery by a hydrogel patch formulation.

    abstract::We have developed a hydrogel patch, which could promote antigen penetration through stratum corneum (SC), and have demonstrated its safety and efficacy in animals and humans. For the availability improvement of our system, it is important to develop a device, which enhances antigen penetration through SC more efficien...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Matsuo K,Ishii Y,Kawai Y,Saiba Y,Quan YS,Kamiyama F,Hirobe S,Okada N,Nakagawa S

    更新日期:2013-06-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Himmelstein KJ,Guvenir I,Patton TF

    更新日期:1978-05-01 00:00:00

  • Prediction of the relaxation behavior of amorphous pharmaceutical compounds. I. Master curves concept and practice.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Hilden LR,Morris KR

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Colombo P,Conte U,Caramella C,Geddo M,La Manna A

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  • Evaluation of degradation pathways for plasmid DNA in pharmaceutical formulations via accelerated stability studies.

    abstract::The stability of highly purified supercoiled plasmid DNA formulated in simple phosphate or Tris-buffered saline solutions has been characterized to establish the overall degradation processes that occur during storage in aqueous solution. Plasmid DNA stability was monitored during accelerated stability studies (at 50 ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Evans RK,Xu Z,Bohannon KE,Wang B,Bruner MW,Volkin DB

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  • Trileucine improves aerosol performance and stability of spray-dried powders for inhalation.

    abstract::For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be on the order of a few micrometers but also they have to be chemically and physically stable. Manufacture of respirable particles is a technical challenge because as particles are reduced in size by conventional milling techniq...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lechuga-Ballesteros D,Charan C,Stults CL,Stevenson CL,Miller DP,Vehring R,Tep V,Kuo MC

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  • Synthesis and anti-inflammatory activity of 3-(benzylideneamino)coumarins in rodents.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Maddi V,Raghu KS,Rao MN

    更新日期:1992-09-01 00:00:00

  • Shear-induced degradation of plasmid DNA.

    abstract::The majority of gene therapy clinical trials use plasmid DNA that is susceptible to shear-induced degradation. Many processing steps in the extraction, purification, and preparation of plasmid-based therapeutics can impart significant shear stress that can fracture the phosphodiester backbone of polynucleotides, and r...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Lengsfeld CS,Anchordoquy TJ

    更新日期:2002-07-01 00:00:00

  • Isolation of 19alpha-H-lupeol from Maclura pomifera.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gearien JE,Klein M

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  • Oxidation of human insulin-like growth factor I in formulation studies. 3. Factorial experiments of the effects of ferric ions, EDTA, and visible light on methionine oxidation and covalent aggregation in aqueous solution.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Fransson JR

    更新日期:1997-09-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wan LS

    更新日期:1977-12-01 00:00:00

  • Experimental evaluation of a model for predicting micellar composition and concentration of monomeric species in bile salt binary mixtures.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Roda A,Cerré C,Fini A,Sipahi AM,Baraldini M

    更新日期:1995-05-01 00:00:00

  • Physicochemical property modification strategies based on enzyme substrate specificities II: alpha-chymotrypsin hydrolysis of aspirin derivatives.

    abstract::Three aspirin derivatives, aspirin phenylalanine ethyl ester, aspirin phenylalanine amide, and aspirin phenyllactic ethyl ester, were investigated with respect to their hydrolysis by alpha-chymotrypsin. Of the three compounds, aspirin phenylalanine ethyl ester was the best substrate, with kcat = 25 sec-1 and Km = 1.3 ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Banerjee PK,Amidon GL

    更新日期:1981-12-01 00:00:00

  • Chemical modifications of therapeutic proteins induced by residual ethylene oxide.

    abstract::Ethylene oxide (EtO) is widely used in sterilization of drug product primary containers and medical devices. The impact of residual EtO on protein therapeutics is of significant interest in the biopharmaceutical industry. The potential for EtO to modify individual amino acids in proteins has been previously reported. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chen L,Sloey C,Zhang Z,Bondarenko PV,Kim H,Ren D,Kanapuram S

    更新日期:2015-02-01 00:00:00

  • Ionophoric properties of polysorbate 80.

    abstract::Polysorbate 80, a surfactant often assumed to be inert, was found to bind a number of biochemically important ions (K+, Na+, NH4+, Ca2+) and transport them through a model membrane (CH2Cl2). The rates and fluxes of potassium ions were found to depend on the initial concentration of potassium ion, the polysorbate 80 co...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Thoman CJ

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  • Water/n-octanol partition coefficients of 1,2-dithiole-3-thiones.

    abstract::Water/n-octanol partition coefficients (log P) for 33 1,2-dithiole-3-thiones and for 18 1,2-dithiol-3-ones were determined by RP-HPLC measurement of the concentration of the solute in aqueous solution after equilibrium. Depending on the nature of the substituents (alkyl or aryl) and their position(s) (4,5, or both) on...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bona M,Boudeville P,Zekri O,Christen MO,Burgot JL

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    journal_title:Journal of pharmaceutical sciences

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    authors: Shawer M,Greenspan P,ØIe S,Lu DR

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Liang LS,Wong W,Burt HM

    更新日期:2005-06-01 00:00:00

  • Exploring a Kinetic Model Approach in Biopharmaceutics: Estimating the Fraction Absorbed of Orally Administered Drugs in Humans.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chiang PC,Liu J,Fan P,Wong H

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sambhi MP,Kannan R,Thananopavarn C,Ookhtens M,Gudenzi M

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Mihaly GW,Cockbain S,Jones DB,Hanson RG,Smallwood RA

    更新日期:1982-05-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Shi L,Sanyal G,Ni A,Luo Z,Doshna S,Wang B,Graham TL,Wang N,Volkin DB

    更新日期:2005-07-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lui CY,Amidon GL,Goldberg A

    更新日期:1991-12-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hansson AG,Giardino A,Cardinal JR,Curatolo W

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bates TR,Carrigan PJ

    更新日期:1975-09-01 00:00:00