Simultaneous high-performance liquid chromatographic determination of chlordiazepoxide and amitriptyline hydrochloride in two-component tablet formulations.

Abstract:

:A rapid, precise, and accurate high-performance liquid chromatographic procedure is presented for the stimultaneous determination of amitriptyline hydrochloride and chlordiazepoxide in two-component tablet formulations. The impurities and decomposition products of both components were separated, making the determination specific for amitriptyline hydrochloride and chlordiazepoxide. The method was used for the assay, content uniformity, and dissolution testing of dosage forms containing 5--30 mg of chlordiazepoxide and 12.5--75 mg of amitriptyline.

journal_name

J Pharm Sci

authors

Burke D,Sokoloff H

doi

10.1002/jps.2600690204

subject

Has Abstract

pub_date

1980-02-01 00:00:00

pages

138-40

issue

2

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)43077-1

journal_volume

69

pub_type

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