Abstract:
:Since its inception in the 1930s, disintegration testing has become an important quality control (QC) test in pharmaceutical industry, and disintegration test procedures for various dosage forms have been described by the different pharmacopoeias, with harmonization among them still not quite complete. However, because of the fact that complete disintegration does not necessarily imply complete dissolution, much more research has been focused on dissolution rather than on disintegration testing. Nevertheless, owing to its simplicity, disintegration testing seems to be an attractive replacement to dissolution testing as recognized by the International Conference on Harmonization guidelines, in some cases. Therefore, with proper research being carried out to overcome the associated challenges, the full potential of disintegration testing could be tapped saving considerable efforts allocated to QC testing and quality assurance.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Al-Gousous J,Langguth Pdoi
10.1002/jps.24303subject
Has Abstractpub_date
2015-09-01 00:00:00pages
2664-75issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(16)30051-Xjournal_volume
104pub_type
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