High-pressure liquid chromatographic determination of ibuprofen in plasma.

Abstract:

:A sensitive, simple, and rapid method for the quantitation of ibuprofen in plasma, using 1-(p-fluorobenzoyl)-5-methoxy-2-methylindole acetic acid as the internal standard, was developed. The method is based on reversed-phase high-pressure liquid chromatography with a mobile phase containing acetonitrile--0.1 M acetic acid (55:45 v/v). The chromatographic elution time was 8.5 min, and ibuprofen quantities as low as 0.1 microgram/ml can be assayed. The suitability of the method is demonstrated.

journal_name

J Pharm Sci

authors

Ali A,Kazmi S,Plakogiannis FM

doi

10.1002/jps.2600700829

subject

Has Abstract

pub_date

1981-08-01 00:00:00

pages

944-5

issue

8

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)43808-0

journal_volume

70

pub_type

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