Abstract：
:The salting in and salting out of the nonionic surfactant octoxynol NF by halides of ammonium and the four lowest symmetrical tetraalkylammonium cations were investigated by measuring their effect on the cloud point at various salt concentrations. The chloride anion tended to salt the surfactant out, lowering its cloud point. The iodide anion tended to salt it in, raising the cloud point, while the bromide ion had no pronounced effect. The ammonium and tetramethylammonium cations tended to lower the cloud point, the latter more extensively than the former. The tetraethylammonium cation had no pronounced effect, while the tetra-n-propylammonium and tetra-n-butylammonium cations tended to raise the cloud point, the latter more extensively than the former. The salt effect on the cloud point generally increased with increasing salt concentration. Tetramethylammonium chloride was the most efficient salt in lowering the cloud point (by 4 degrees at the 0.10-molal level and by 20 degrees at the 1.00-molal level), while tetrabutylammonium halides were the most efficient salts in raising the cloud point (by 18-19 degrees at the 0.10-molal level for chloride and bromide). Cloud point increased were attributed to the formation of mixed micelles or to hydrotropy. The salting-out efficiency of tetramethylammonium chloride and bromide was ascribed to their ability to increase the structure of water.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Schott H,Han SKdoi
10.1002/jps.2600660208subject
Has Abstractpub_date
1977-02-01 00:00:00pages
165-8issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(15)39197-8journal_volume
66pub_type
杂志文章abstract：:Progesterone release from monolithic devices prepared from various copolymers of poly(hydroxyethyl methacrylate) and poly(methoxyethoxyethyl methacrylate) or poly(methoxyethyl methacrylate) was examined. In general, plots of the fraction of drug released versus (time)1/2 were linear during the early stages of drug rel...
journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600700226
更新日期：1981-02-01 00:00:00
abstract：:Papers and patents that deal with polymorphism (crystal systems for which a substance can exist in structures characterized by different unit cells, but where each of the forms has exactly the same elemental composition) and solvatomorphism (systems where the crystal structures of the substance are defined by differen...
journal_title：Journal of pharmaceutical sciences
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abstract：:α-Lipoic acid (ALA) is a powerful antioxidant valuable for prevention and treatment of ophthalmic complications such as diabetic keratopathy and retinopathy. The aim of this work was to develop micelle-based formulations that can enhance the solubility, stability, and corneal permeability of ALA. Compared to a convent...
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journal_title：Journal of pharmaceutical sciences
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doi：10.1016/j.xphs.2019.10.062
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abstract：:The overall apparent first-order rate constants (Kab) of small intestinal absorption of sulfadiazine were determined in rats in situ at various pHs (4.01-7.42) of the recirculation fluids at 32 degrees. The purpose of the study was to verify our hypothesis that the rate-determining step for the absorption of sulfonami...
journal_title：Journal of pharmaceutical sciences
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更新日期：1994-02-01 00:00:00
abstract：:Alpha-Hydroxyaryl ketones such as 2-hydroxypropiophenone and 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone, the key intermediates in the preparation of antifungal agents, decompose into oxidized, rearranged, and condensed products. These products were isolated and characterized. The possible mechanisms for the formatio...
journal_title：Journal of pharmaceutical sciences
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更新日期：1992-12-01 00:00:00
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更新日期：2014-08-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.22295
更新日期：2011-02-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：1989-07-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：1985-12-01 00:00:00
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更新日期：2016-07-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.20120
更新日期：2004-09-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章,评审
doi：10.1002/jps.21286
更新日期：2008-10-01 00:00:00
abstract：:As part of a study to examine cocaine disposition and interaction with ethanol, it was necessary to characterize various properties of cocaine in the blood of the experimental animal. All studies were conducted using blood from healthy adult male Sprague-Dawley rats. Cocaine was incubated in whole blood at 37 degrees ...
journal_title：Journal of pharmaceutical sciences
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doi：10.1021/js960026h
更新日期：1996-06-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.20794
更新日期：2007-06-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600830408
更新日期：1994-04-01 00:00:00
abstract：:Though there is an advantage in using the higher solubility amorphous state in cases where low solubility limits absorption, physical instability poses a significant barrier limiting its use in solid oral dosage forms. Unlike chemical instability, where useful accelerated stability testing protocols are common, no met...
journal_title：Journal of pharmaceutical sciences
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更新日期：2008-04-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：2014-08-01 00:00:00
abstract：:Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all the organs. It is treated by the 6-h oral administration of the aminothiol, cysteamine, which has an offensive taste and smell. In an attempt to reduce this frequency and improve the tr...
journal_title：Journal of pharmaceutical sciences
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更新日期：1986-07-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600650135
更新日期：1976-01-01 00:00:00
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更新日期：2015-06-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：2001-02-01 00:00:00
abstract：:Baclofen, a widely used antispastic agent, has been found to exist in two crystalline forms, the anhydrate and monohydrate. The aim of this study was (1) to identify and characterize these two solid phases of baclofen, and (2) to examine the processing-induced phase transformations associated with wet granulation of b...
journal_title：Journal of pharmaceutical sciences
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更新日期：2007-09-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：2008-04-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：2000-10-01 00:00:00
abstract：:New butyrate derivatives were synthesized to investigate the residence time of potent butyric acid in vivo. These derivatives were triglycerides in which one, two, or three butyric acid molecules were bound to glycerol or to mono- and dipalmitic esters of glycerol. Pharmacokinetic studies showed that a constant plasma...
journal_title：Journal of pharmaceutical sciences
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doi：
更新日期：1993-10-01 00:00:00
abstract：:The nanosizing of poorly soluble drugs as a formulation strategy can eventually enhance their dissolution rate and bioavailability. Standard comminution techniques such as high-pressure homogenization (HPH) or wet bead milling have limitations in reaching the desired mean particle size. Combinative methods have been d...
journal_title：Journal of pharmaceutical sciences
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更新日期：2013-05-01 00:00:00
