Abstract:
:A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Diethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in an in vitro diffusion cell model. A topically applied steroid, hydrocortisone, has been used to demonstrate the in vivo effectiveness of I on human skin. The degree of pallor produced on human skin by the corticosteroids was used as a measure of the relative delivery of hydrocortisone from formulations with and without I.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Windheuser JJ,Haslam JL,Caldwell L,Shaffer RDdoi
10.1002/jps.2600711107subject
Has Abstractpub_date
1982-11-01 00:00:00pages
1211-3issue
11eissn
0022-3549issn
1520-6017pii
S0022-3549(15)44399-0journal_volume
71pub_type
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