Abstract:
:A rapid and accurate method for the quantitative determination of the extent and ratio of amino and carboxyl group trimethylsilylation of 6-aminopenicillanic acid, 7-amino-3-methyl-delta3-cephem-4-carboxylic acid, and 7-amino-3-acetoxymethyl-delta3-cephem-4-carboxylic acid is presented. The method utilizes NMR spectroscopy and is based on the difference in chemical shifts between N-trimethylsilyl and O-trimethylsilyl groups or, in cephalosporin derivatives, between the methyl group in the 3-position and free amino resonances. The spectra of the N,O-bis(trimethylsilyl) derivatives are discussed.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Bortesi F,Cavalli S,Mangia Adoi
10.1002/jps.2600661230subject
Has Abstractpub_date
1977-12-01 00:00:00pages
1767-9issue
12eissn
0022-3549issn
1520-6017pii
S0022-3549(15)39735-5journal_volume
66pub_type
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