Abstract:
:A novel method was established for the preparation of Eudragit S, Eudragit L, and Eudispert high-viscosity (hv) hydrogel and xerogel preparations containing a medicinal component such as pentoxifylline (an agent that improves cerebral microcirculation). A significant correlation was found between the in vitro mean dissolution time and the in vivo mean residence time of pentoxifylline after rectal administration of these preparations in rabbits. Staying properties of the hydrogel and xerogel preparations in the lower part of the rectum were compared with those of polyethylene glycol 2000 and Witepsol S-55 suppositories in rats, with water-insoluble dye. Eudispert hv hydrogel and xerogel preparations have excellent staying properties in the rectum. The efficacy of Eudispert hv xerogel preparations may be reduced by first passage through the liver after oral administration.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Kim NS,Kawata M,Uchida T,Goto Sdoi
10.1002/jps.2600810613subject
Has Abstractpub_date
1992-06-01 00:00:00pages
537-40issue
6eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48866-5journal_volume
81pub_type
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