Abstract:
:The hydrolysis of acetylcholine and acetylcholine mustard by acetylcholinesterase was compared over a substrate concentration range of 1-10 mM. Reactions were allowed to proceed for 2 min at 25 degrees. Results of these experiments reveal that the substrates have similar affinities for the enzyme, whereas the maximum velocity for the hydrolysis of acetylcholine mustard was significantly lower than for acetylcholine. These findings suggest that acetylcholine mustard has the ability to inactive acetycholinesterase.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Hudgins PM,Stubbins JFdoi
10.1002/jps.2600640839subject
Has Abstractpub_date
1975-08-01 00:00:00pages
1419-21issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(15)40335-1journal_volume
64pub_type
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journal_title:Journal of pharmaceutical sciences
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abstract::Poly(methyl [1-14C]methacrylate) nanoparticles were injected subcutaneously into rats. Almost all of the radioactivity stayed at the injection site. After an initial urinary and fecal excretion of approximately 1% of the administered dose per day, the rate of elimination dropped to a low level (approximately 0.005%/da...
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journal_title:Journal of pharmaceutical sciences
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