Abstract:
:(13)C labeling was used to enhance the sensitivity of (13)C solid-state NMR to study the effect of tabletting on the polymorphism of a steroidal drug. The steroidal drug Org OD 14 was (13)C labeled and formulated into tablets containing only 0.5-2.5% active ingredient. The tablets were subsequently studied by solid-state (13)C CPMAS NMR. The crystalline form present in tablets could readily be analyzed in tablets. No change in crystalline form was observed as a result of formulation or in subsequent stability studies. Solid-state NMR in combination with (13)C labeling can, in suitable cases, be used as a strategy to study the effect of formulation on the polymorphism of low dose drugs.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Booy KJ,Wiegerinck P,Vader J,Kaspersen F,Lambregts D,Vromans H,Kellenbach Edoi
10.1002/jps.20236subject
Has Abstractpub_date
2005-02-01 00:00:00pages
458-63issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(16)31698-7journal_volume
94pub_type
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