Abstract:
:Drugs possessing the ability to bind to melanin-rich tissue, such as the eye, are linked with higher ocular exposure, and therefore have the potential to affect the efficacy and safety profiles of therapeutics. A high-throughput melanin chromatographic affinity assay has been developed and validated, which has allowed the rapid melanin affinity assessment for a large number of compounds. Melanin affinity of compounds can be quickly assigned as low, medium, or high melanin binders. A high-throughput chromatographic method has been developed and fully validated to assess melanin affinity of pharmaceuticals and has been useful in predicting ocular tissue distribution in vivo studies. The high-throughput experimental approach has also allowed for a specific training set of 263 molecules for a quantitative structure-affinity relationships (QSAR) method to be developed, which has also been shown to be a predictor of ocular tissue exposure. Previous studies have reported the development of in silico QSAR models based on training sets of relatively small and mostly similar compounds; this model covers a broader range of melanin-binding affinities than what has been previously published and identified several physiochemical descriptors to be considered in the design of compounds where melanin-binding modulation is desired.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Reilly J,Williams SL,Forster CJ,Kansara V,End P,Serrano-Wu MHdoi
10.1002/jps.24680subject
Has Abstractpub_date
2015-12-01 00:00:00pages
3997-4001issue
12eissn
0022-3549issn
1520-6017pii
S0022-3549(15)50981-7journal_volume
104pub_type
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