Abstract:
:Many pharmaceuticals are formulated as powders to aid drug delivery. A major problem is how to produce powders having high purity, controlled morphology, and retained bioactivity. We demonstrate the use of supercritical carbon dioxide as an antisolvent for meeting this need for two model drug systems, quercetin, a sparingly soluble antioxidant, and short interfering RNA (siRNA), which can silence genes. In both cases we achieve retention of bioactivity as well as a narrow particle size distribution in which the particles are free of impurities.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Jacobson GB,Shinde R,McCullough RL,Cheng NJ,Creasman A,Beyene A,Hickerson RP,Quan C,Turner C,Kaspar RL,Contag CH,Zare RNdoi
10.1002/jps.22035subject
Has Abstractpub_date
2010-06-01 00:00:00pages
2750-5issue
6eissn
0022-3549issn
1520-6017pii
S0022-3549(15)32608-3journal_volume
99pub_type
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