Abstract:
:A consistent account of the assumptions of the well-stirred perfusion limited model leads to the equation for the organ tissue that does not coincide with that often presented in books and papers. The difference in pharmacokinetic profiles calculated by the valid and the commonly used equations could be quite significant, particularly due to contribution of the organs with relatively large perfusion volume, and especially for drugs with small tissue-plasma partition coefficient and high blood-plasma concentration ratio. Application of the valid equation may result in much faster initial drop of drug plasma concentration time curve and significantly longer terminal half-life, especially for low extraction ratio drugs. An equation for the steady state volume of distribution consistent with the well-stirred model described by the valid equation is provided.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Berezhkovskiy LMdoi
10.1002/jps.21798subject
Has Abstractpub_date
2010-01-01 00:00:00pages
475-85issue
1eissn
0022-3549issn
1520-6017pii
S0022-3549(16)30348-3journal_volume
99pub_type
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