Abstract:
:A specific, sensitive, rapid, and reproducible analytical GLC method for lidocaine in human plasma, including pharmacokinetic parameters, is described. Aminopyrine is the internal standard. The method was used to study pharmacokinetics in four healthy volunteers following the administration of a lidocaine bolus at a dose of 1 mg/kg iv and in one patient with cardiac arrhythmias who had been given a 50-mg bolus followed by a prolonged intravenous infusion for 30 hr.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Caille G,Lelorier J,Latour Y,Besner JGdoi
10.1002/jps.2600661007subject
Has Abstractpub_date
1977-10-01 00:00:00pages
1383-5issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(15)39621-0journal_volume
66pub_type
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