Abstract：
:The solubility of butamben has been measured gravimetrically in pure methanol, 1-propanol, 2-propanol, 1-butanol, and toluene over the temperature range 268-298 K. Polymorph transition and melting temperatures, associated enthalpy changes, and the heat capacity of the solid forms and the supercooled melt have been measured by differential scanning calorimetry. Based on extrapolated calorimetric data, the Gibbs energy, enthalpy and entropy of fusion, and the activity of solid butamben (the ideal solubility) have been calculated from below ambient temperature up to the melting point. Activity coefficients of butamben at equilibrium in the different solvents have been estimated from solubility data and the activity of the solid, revealing that all investigated systems exhibit positive deviation from Raoult's law. Solubility data are well correlated by a semiempirical regression model. On a mass basis, the solubility is clearly higher in methanol than in the other solvents, but mole fraction solubilities are very similar across all 5 solvents. The 2 known polymorphs are enantiotropically related, and the transition point is located at 283 K. Polymorph interconversions occur within 0.3 K of the transition point even in the solid state, and the 2 forms exhibit strong similarities in investigated properties.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Svärd M,Zeng L,Valavi M,Krishna GR,Rasmuson ÅCdoi
10.1016/j.xphs.2019.02.013subject
Has Abstractpub_date
2019-07-01 00:00:00pages
2377-2382issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(19)30129-7journal_volume
108pub_type
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