Abstract:
:Spectrophotometric assay for cycloserine based on the interaction of the drug with 9-methoxyacridine as a chromogenic agent is described. The highly colored substituted acridine product was identified as 9-(d-4-imino-3-isoxazolidinone)acridine. Color development was affected by time and temperature of heating and by the quantity of 9-methoxyacridine reagent utilized. The absorbance at 438 nm is linearly proportional to concentrations of cycloserine with a detection limit of 0.3 microgram/mL. The optimum range for the assay of cycloserine was from 5.0 X 10(-6) to 3.0 X 10(-4) M (correlation coefficient = 0.9999, n = 6). When applied to cycloserine capsules labeled to contain 250 mg, the proposed method gave mean recoveries of 101.84 +/- 0.48%. The procedure is sufficiently sensitive, precise, and accurate for the determination of cycloserine in its dosage form.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Stewart JT,Yoo GSdoi
10.1002/jps.2600770519subject
Has Abstractpub_date
1988-05-01 00:00:00pages
452-4issue
5eissn
0022-3549issn
1520-6017pii
S0022-3549(15)47691-9journal_volume
77pub_type
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journal_title:Journal of pharmaceutical sciences
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