Anthrax vaccine powder formulations for nasal mucosal delivery.

abstract：:The antimalarial endoperoxides, such as artemisinin, are postulated to exert their potent parasiticidal activity via the formation of reactive intermediates in the iron-rich infected erythrocyte. The in vitro chemical reaction profile of putative endoperoxide antimalarials and ferrous iron is often qualitatively used ...

journal_title：Journal of pharmaceutical sciences

authors： Creek DJ,Chiu FC,Prankerd RJ,Charman SA,Charman WN

更新日期：2005-08-01 00:00:00

abstract：:The crystallization tendency of 2 crystalline polymorphs of indomethacin (Iα, Iγ) in the undercooled melt has been investigated using molecular dynamics simulations. The main thermodynamical and dynamical physical parameters involved in the nucleation and growth processes have been determined. A careful attention has ...

journal_title：Journal of pharmaceutical sciences

authors： Gerges J,Affouard F

更新日期：2020-02-01 00:00:00

abstract：:Injectable controlled-release formulations are of increasing interest for the treatment of chronic diseases. This study aims to develop and characterize a polymeric matrix for intramuscular or subcutaneous injection, consisting of two biocompatible polymers, particularly suitable for formulating poorly soluble drugs. ...

journal_title：Journal of pharmaceutical sciences

authors： Meeus J,Chen X,Scurr DJ,Ciarnelli V,Amssoms K,Roberts CJ,Davies MC,van Den Mooter G

更新日期：2012-09-01 00:00:00

abstract：:A pharmacokinetic study of the dopamine D2 receptor agonist (S)-(-)-2-(N-propyl-N-(2-thienylethyl)amino)-5-hydroxytetralin+ ++-HCl (N-0923) infused in female cynomolgus monkeys over a 4-h period was carried out at International Research and Development Corporation. The purpose of this study was to estimate the elimina...

journal_title：Journal of pharmaceutical sciences

authors： Walters DR,McConnell WR,Cefali EA

更新日期：1994-05-01 00:00:00

abstract：:A GLC method is described for the determination of iminodibenzyl and desipramine impurities in imipramine hydrochloride and its formulated products. These impurities were extracted from an alkaline solution with a mixture of 30% methylene chloride in hexane for chromatography on a 3% OV-17 GLC column. Iminodibenzyl wa...

journal_title：Journal of pharmaceutical sciences

authors： Thompson DW

更新日期：1982-05-01 00:00:00

abstract：:The chemical shifts of the methyl groups of 2,4-dimethylbenzo[g]quinoline are defined with respect to concentration, showing that the methyl resonances are reversed from their expected positions in concentrations normally used in NMR spectroscopy. The phenomenon is explained in terms of the probably "fixation" of bond...

journal_title：Journal of pharmaceutical sciences

authors： Born JL,Harsin CE

更新日期：1977-08-01 00:00:00

abstract：:Prostaglandin F2 alpha was administered intraamniotically to 132 mid-first trimester gravidas to determine the dose-24-hour abortifacient response relationship. Single doses between 15-50 mg and multiple doses between 15-25 mg were administered to 3 groups each, the latter regimen at 6-hour intervals. Trials were de...

journal_title：Journal of pharmaceutical sciences

authors： Brenner WE,Hendricks CH,Fishburne JI Jr,Staurovsky L,Braaksma J,Taft R

更新日期：1973-08-01 00:00:00

abstract：:In this study a 3D printed capsule designed to break from the physiological pressures in the antropyloric region was evaluated for its ability to deliver the synthetic octapeptide octreotide in beagle dogs when co-formulated with the permeation enhancer sodium caprate. The pressure sensitive capsules were compared to ...

journal_title：Journal of pharmaceutical sciences

authors： Berg S,Krause J,Björkbom A,Walter K,Harun S,Granfeldt A,Janzén D,Nunes SF,Antonsson M,Van Zuydam N,Skrtic S,Hugerth A,Weitschies W,Davies N,Abrahamsson B,Bergström CAS

更新日期：2021-01-01 00:00:00

abstract：:Colonic drug delivery is intended for local or systemic therapies. The lack of predictive in vitro or animal model leads to considerable time delays in colonic product development. The objective of this scintigraphic study was to provide "proof of concept" for a novel capsule-type colonic delivery system (Colon-Target...

journal_title：Journal of pharmaceutical sciences

authors： Ishibashi T,Pitcairn GR,Yoshino H,Mizobe M,Wilding IR

更新日期：1998-05-01 00:00:00

abstract：:Hydroxypropyl cellulose films were prepared by compression molding of three different lots of hydroxypropyl cellulose powder at 149 degrees C, 188 degrees C, and 232 degrees C. Rectangular pieces were cut from these films and viscosity average molecular weight (Mv), degree of orientation, and rate of dissolution were ...

journal_title：Journal of pharmaceutical sciences

authors： Grabowski LA,Bondi JV,Harwood RJ

更新日期：1985-05-01 00:00:00

abstract：:The distribution of zidovudine (AZT) between plasma, brain extracellular fluid (ECF), and cerebrospinal fluid (CSF) was investigated in a crossover design study (n = 5) in unanesthetized rabbits. Drug was administered by intravenous (iv) and intracerebroventricular (icv) infusions at the same infusion rate (1.5 mg/h.k...

journal_title：Journal of pharmaceutical sciences

authors： Wang Y,Sawchuk RJ

更新日期：1995-07-01 00:00:00

abstract：:The kinetic profile for the decomposition of ditiocarb sodium salt in aqueous solution was achieved with UV-visible absorption spectrometry. The kinetic profile indicates that the decomposition reaction is hydrogen ion-catalyzed over the entire 4-10 pH range and enables the determination of the value of the acid-base ...

journal_title：Journal of pharmaceutical sciences

authors： Martens T,Langevin-Bermond D,Fleury MB

更新日期：1993-04-01 00:00:00

abstract：:For development and optimization of protein formulation sensitive analytical tools are required to follow both aggregation and changes in protein structure. The latter can be seen as the beginning of physical instability leading to aggregation. The focus of this work laid on the development of a novel analysis simulta...

journal_title：Journal of pharmaceutical sciences

authors： Printz M,Friess W

更新日期：2012-02-01 00:00:00

abstract：:An assay for gold in whole blood of arthritis patients was developed using the graphite furnace atomic absorption spectrophotometer. This method involves no pretreatment of the whole blood except for simple dilution, thereby eliminating some variables and saving laboratory time and expense. ...

journal_title：Journal of pharmaceutical sciences

authors： Barrett MJ,DeFries R,Henderson WM

更新日期：1978-09-01 00:00:00

abstract：:The stereochemistries of geometric isomers of 4-(2-bromo-1,2-diphenylvinyl)phenol, 4-(2-bromo-1,2-diphenylvinyl)anisole, and 2-[p-(2-bromo-1,2-diphenylvinyl)phenoxy]triethylamine were determined by conversion of the phenolic analog to the ethers and subsequent comparison of physical properties with those of 2-[p-(2-ch...

journal_title：Journal of pharmaceutical sciences

authors： Richardson A Jr,Benson HD,Hite G

更新日期：1976-10-01 00:00:00

abstract：:Condensations of carbon disulfide were carried out with amino, chloro, and diamino heterocycles to give condensed ring thiazoline-2-thiones and imidazoline-2-thiones, with cyanomethyl heterocycles to give dithio acid derivatives, and with heterocyclic sulfonamides to give sulfonyldithiocarbamates. Of several examples ...

journal_title：Journal of pharmaceutical sciences

authors： Foye WO,Kauffman JM,Lanzillo JJ,LaSala EF

更新日期：1975-08-01 00:00:00

abstract：:P,P-Bis(1-aziridinyl)-N-1-adamantylphosphinic amide displayed oncolytic activity against intracerebral and intraperitoneal L-1210 leukemia. Administration of the isotope-labeled compound to rats shows 32P distribution to the brain. ...

journal_title：Journal of pharmaceutical sciences

authors： Cates LA,Cramer MB

更新日期：1976-03-01 00:00:00

abstract：:An extension of the Bischoff-Dedrick pharmacokinetic model is presented. This model is derived from basic considerations of drug distrubition with physiological and anatomical meaning. The Bischoff-Dedrick model can simultaneously predict drug distribution with time in blood, organs, and tissues of pharmacological int...

journal_title：Journal of pharmaceutical sciences

authors： Chen CN,Andrade JD

更新日期：1976-05-01 00:00:00

abstract：:Protein and peptide antigens frequently are only slightly immunogenic when utilized alone in vaccines. Formulation of these antigens in a carrier vehicle, particularly when an adjuvant is included, often results in markedly enhanced immune responses. Encapsulation of peptide and protein antigens in liposomes generally...

journal_title：Journal of pharmaceutical sciences

authors： Richards RL,Alving CR,Wassef NM

更新日期：1996-12-01 00:00:00

abstract：:To study if electrostatic charge initially present in mannitol powder plays a role in the generation of aerosols, mannitol was unipolarly charged to varying magnitudes by tumbling the powder inside containers of different materials. The resulting charge in the powder was consistent with predictions from the triboelect...

journal_title：Journal of pharmaceutical sciences

authors： Adi H,Kwok PC,Crapper J,Young PM,Traini D,Chan HK

更新日期：2010-05-01 00:00:00

abstract：:A high-pressure liquid chromatographic method for the sensitive, rapid, and specific determination of sulfapyridine and its N-acetyl derivative in plasma and saliva was developed. A cyano-bonded, reversed-phase, high efficiency column was used. The system detected these sulfonamides in serum to 0.25 mg/liter and withi...

journal_title：Journal of pharmaceutical sciences

authors： Owerbach J,Johnson NF,Bates TR,Pieniaszek HJ Jr,Jusko WJ

更新日期：1978-09-01 00:00:00

abstract：:There is a growing interest in developing inhibitors of the neonatal Fc-receptor, FcRn, for use in the treatment for humoral autoimmune conditions. We have developed a new physiologically based pharmacokinetic model that is capable of characterizing the pharmacokinetics and pharmacodynamics of anti-FcRn monoclonal ant...

journal_title：Journal of pharmaceutical sciences

authors： Li T,Balthasar JP

更新日期：2019-01-01 00:00:00

abstract：:Currently, the EMEA, FDA, and WHO as regulatory authorities accept rapidly dissolving (>85% dissolved in 30 min) biopharmaceutics classification system (BCS) I drug products for biowaiver candidates. In the draft EMEA guideline the requirement has been set tighter, that is, the drug product should be very rapidly diss...

journal_title：Journal of pharmaceutical sciences

authors： Kortejärvi H,Shawahna R,Koski A,Malkki J,Ojala K,Yliperttula M

更新日期：2010-02-01 00:00:00

abstract：:Multidrug resistance (MDR) mediated by the overexpression of the drug efflux protein P-glycoprotein is one of the major obstacles to successful cancer chemotherapy. The development of safe and effective MDR-reversing agents is an important approach to addressing this problem clinically. In this study, we evaluated the...

journal_title：Journal of pharmaceutical sciences

authors： Liu R,Zhang Y,Chen Y,Qi J,Ren S,Xushi MY,Yang C,Zhu H,Xiong D

更新日期：2010-07-01 00:00:00

abstract：:The objective of this study was to identify the important factors that determine plasma concentrations of diphenhydramine (DPHM) in the mother and the fetus after maternal as well as fetal steady-state drug administration. Inter-relationships were evaluated between maternal and fetal placental and nonplacental clearan...

journal_title：Journal of pharmaceutical sciences

authors： Kumar S,Tonn GR,Riggs KW,Rurak DW

更新日期：1999-12-01 00:00:00

abstract：:The purpose of the study is to understand the effect of altitude on the performance of selected pressurized metered dose inhalers (pMDIs) and dry powder inhalers (DPIs). A testing apparatus that created consistent breath profiles through the Alberta Idealized Throat was designed to test five pMDIs and two DPIs at alti...

journal_title：Journal of pharmaceutical sciences

authors： Titosky JTF,Morin CMD,Suderman JD,Olfert JS,Finlay WH,Vehring R

更新日期：2014-07-01 00:00:00

abstract：:Quantitative prediction of unbound drug fraction (fu) is essential for scaling pharmacokinetics through physiologically based approaches. However, few attempts have been made to evaluate the projection of fu values under pathological conditions. The primary objective of this study was to predict fu values (n = 105) of...

journal_title：Journal of pharmaceutical sciences

authors： Li GF,Yu G,Li Y,Zheng Y,Zheng QS,Derendorf H

更新日期：2018-07-01 00:00:00

abstract：:A hollow cylinder intravitreal implant was developed to achieve sustained release of protein to the retina for the treatment of retinal diseases. Hollow cylinders were fabricated by molding and cross-linking hyaluronic acid, the major component of the vitreous humor. Hollow cylinders were filled with a concentrated pr...

journal_title：Journal of pharmaceutical sciences

authors： Van Kampen E,Vandervelden C,Fakhari A,Qian J,Berkland C,Gehrke SH

更新日期：2018-09-01 00:00:00

abstract：:Historically, recovery had been used to evaluate the data quality of plasma protein binding or tissue binding obtained from equilibrium dialysis assays. Low recovery was often indicative of high nonspecific binding, instability, or low solubility. This study showed that, when equilibrium was fully established in the d...

journal_title：Journal of pharmaceutical sciences

authors： Di L,Umland JP,Trapa PE,Maurer TS

更新日期：2012-03-01 00:00:00

abstract：:Biopharmaceuticals represent an important and growing class of medicines. Immunogenic responses to biopharmaceuticals in patients can sometimes result in reduced safety and efficacy. Although multiple factors are known to influence immunogenicity, our understanding of the complex underlying mechanisms remains imperfec...

journal_title：Journal of pharmaceutical sciences

authors： Bee JS,Goletz TJ,Ragheb JA

更新日期：2012-10-01 00:00:00