Abstract:
:Condensations of carbon disulfide were carried out with amino, chloro, and diamino heterocycles to give condensed ring thiazoline-2-thiones and imidazoline-2-thiones, with cyanomethyl heterocycles to give dithio acid derivatives, and with heterocyclic sulfonamides to give sulfonyldithiocarbamates. Of several examples tested, pyrido[3,2-d]thiazoline-2-thione, disodium 2-(5-chloro-2-thienyl)-3,3-dimercaptoacrylonitrile, triethylammonium 4-sulfamoylphenyldithiocarbamate, ammonium beta-phenethyldithiocarbamate, and methyl N-(thiophene-2-sulfonyl)dithiocarbamate, only the last-named compound showed any radiation protection for mice. Several compounds gave negative tests for antimalarial activity.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Foye WO,Kauffman JM,Lanzillo JJ,LaSala EFdoi
10.1002/jps.2600640823subject
Has Abstractpub_date
1975-08-01 00:00:00pages
1371-4issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(15)40322-3journal_volume
64pub_type
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